In 2019,Materials Science & Engineering, C: Materials for Biological Applications included an article by Veisi, Hojat; Safarimehr, Parisa; Hemmati, Saba. Application of 623-00-7. The article was titled 《Buchwald-Hartwig C-N cross coupling reactions catalyzed by palladium nanoparticles immobilized on thio modified-multi walled carbon nanotubes as heterogeneous and recyclable nanocatalyst》. The information in the text is summarized as follows:
In current research, the multi walled carbon nanotubes were functionalized with mercapto-melamine groups by covalent grafting of f-CNT with ethylenediamine, cyanuric chloride and 2-mercaptoethanol for introducing mercapto functional groups on the surface of nanotube. Consequently, the thiolated MWCNTs were applied to deposing Pd nanoparticles. The results of FTIR, Raman spectroscopy, powder XRD, energy dispersive spectroscopy (EDS), wavelength-dispersive X-ray spectroscopy (WDX) and CHN anal. showed the successful synthesis of nanocatalyst. The scanning and transmission electron microscopes (SEM and TEM) were used to study the morphologies of the nanocatalyst. Moreover, the (MWCNTs/CC-SH/Pd) nanocatalyst was effectively applied in Buchwald-Hartwig C-N cross coupling reaction with wide variety of functionalized substrates, aryl halides 4-RC6H4X (R = H, NC, CH3, CH3O; X = Cl, Br, I) and amines R1H (R1 = morpholin-4yl, phenylaminyl, piperidin-1-yl, etc.). A variety of aryl amines 4-RC6H4R1 was prepared through reaction of aryl halides (chloride, bromide and iodide) and amines in high yields. Remarkably, the new catalyst could be reused for six recycles without change in its catalytic activity. In the experiment, the researchers used 4-Bromobenzonitrile(cas: 623-00-7Application of 623-00-7)
4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Application of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts