Hartz, Richard A.; Ahuja, Vijay T.; Nara, Susheel J.; Kumar, C. M. Vijaya; Manepalli, Raju K. V. L. P.; Sarvasiddhi, Sarat Kumar; Honkhambe, Swarnamba; Patankar, Vidya; Dasgupta, Bireshwar; Rajamani, Ramkumar; Muckelbauer, Jodi K.; Camac, Daniel M.; Ghosh, Kaushik; Pokross, Matthew; Kiefer, Susan E.; Brown, Jeffrey M.; Hunihan, Lisa; Gulianello, Michael; Lewis, Martin; Lippy, Jonathan S.; Surti, Neha; Hamman, Brian D.; Allen, Jason; Kostich, Walter A.; Bronson, Joanne J.; Macor, John E.; Dzierba, Carolyn D. published the artcile< Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors>, SDS of cas: 38487-85-3, the main research area is quinazoline quinoline preparation analgesic AAK1 inhibitor.
Investigation of the structure-activity relationships (SARs) of substituents on the resultant quinazoline and quinoline ring systems led to the identification of (S)- I =[R1 = CN, R2 = H], a brain-penetrant, AAK1-selective inhibitor with improved enzyme and cellular potency. The synthesis, SAR, and in vivo evaluation of a series of quinazoline and quinoline-based AAK1 inhibitors were described herein.
Journal of Medicinal Chemistry published new progress about Analgesics. 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, SDS of cas: 38487-85-3.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts