The author of 《Protective effects of piper betel phenol, hydroxychavicol and its derivatives against rotenone induced neurotoxicity: synthesis, in vitro and in vivo efficacy studies》 were Ghanta, Venkata Rao; Pasula, Aparna; Pindiprolu, Sai Kiran S. S.; Krishnamurthy, Praveen T.; Ravi, Chandran J. K.; Raman, Balamurali. And the article was published in World Journal of Pharmaceutical Research in 2019. Quality Control of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:
Hydroxychavicol or 4-Allylpyrocatechol (4-APC) is a Piper betel phenol, reported to modulate vital pathways involved in inflammation and oxidative stress. However, the potential neuro protective benefits of 4APC against neurodegeneration, where similar pathways are involved was not reported and hence 4APC and its derivatives (3a – 3j) were evaluated for their possible neuroprotective activity against rotenone induced neurotoxicity. In the present study 4-allyl pyrocatechol (APC) and its derivatives (3a – 3j) were synthesized via heck coupling with aryl bromides and evaluated for their possible in vitro and in vivo neuroprotective activity against rotenone induced neurotoxicity in SH-SY5Y cell lines and in Swiss albino mice, resp. In the in vitro studies, among the tested compounds, the 4APC and its derivative, 3c, have shown significant protection against rotenone induced cytotoxicity. In mice, these 2 mols. significantly prevent the rotenone (3 mg/kg, s.c.) induced changes in grip strength, locomotor activity and oxidative & inflammatory stress markers at a tested oral dose of 20/mg/kg. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Quality Control of 4-Bromo-2-fluorobenzonitrile)
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Quality Control of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts