Du, Bingnan; Jiang, Xiaoqing; Sun, Peipei published the artcile< Palladium-Catalyzed Highly Selective ortho-Halogenation (I, Br, Cl) of Arylnitriles via sp2 C-H Bond Activation Using Cyano as Directing Group>, Recommanded Product: 2-Chloro-4-methylbenzonitrile, the main research area is halosuccinimide ortho halogenation arylnitrile palladium catalyst; nitrile aromatic ortho halogenation halosuccinimide palladium catalyst.
A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature Using cyano as the directing group, the halogenation reaction gave good to excellent yields. E.g., in presence of Pd(OAc)2 and p-toluenesulfonic acid, reaction of PhCN and NIS gave 84% 2-IC6H4CN. The method is compatible for arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available at least the gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.
Journal of Organic Chemistry published new progress about Halogenation catalysts. 21423-84-7 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H6ClN, Recommanded Product: 2-Chloro-4-methylbenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts