Yadav, Maruti B.; Bhosle, Suresh R.; Jeong, Yeon Tae published the artcile< DBU-promoted synthesis of novel heterocyclic [4.3.3] propellanes from α-cyanoketones and cyclic α-diketones>, Synthetic Route of 21667-62-9 , the main research area is heterocyclic tetrahydro benzofuran propellane preparation chemoselective diastereoselective one pot; cyclic alpha diketone cyanoketone multicomponent DBU catalyst.
An effective base-catalyzed Knoevenagel, Michael and intramol./Paal-Knorr cyclization strategy for the construction of heterocyclic [4.3.3] tetrahydro epoxyetheno benzo-furan propellanes (TEBFs) from cyclic α-diketones and α-cyanoketones is reported through single-step reaction. The reaction proceeds under mild reaction conditions and shows excellent chemo and diastereoselectivity in the absence of any external transition metal and ligands. The one-pot two-component procedure also shows the merits of straightforward reaction conditions, simple operation, using available feedstock, wide substrate scope, and high atom and step economy. This reaction provides facile access to highly substituted fused tetrahydro furo-furan propellanes, which can be used in the field of chem. and pharmaceutical research.
Tetrahedron Letters published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent) (cyano). 21667-62-9 belongs to class nitriles-buliding-blocks, and the molecular formula is C9H6ClNO, Synthetic Route of 21667-62-9 .
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts