Severin, Rene; Mujahidin, Didin; Reimer, Jessica; Doye, Sven published the artcile< Synthesis of benzylisoquinoline derivatives possessing electron-withdrawing substituents on the benzene ring of the isoquinoline skeleton>, Related Products of 886761-96-2, the main research area is bromophenyl acetonitrile derivative preparation arylacetylene Sonogashira coupling palladium; alkynyl acetonitrile derivative preparation reduction; amino alkyne preparation intramol hydroamination heterocyclization titanium; benzylisoquinoline derivative laudanosine norlaudanosine alkaloid analog preparation; palladium Sonogashira coupling catalyst; titanium intramol hydroamination heterocyclization catalyst.
3,4-Dihydrobenzylisoquinolines and 1,2,3,4-tetrahydrobenzylisoquinolines, e.g., I (R = H or F), possessing electron withdrawing substituents on the benzene ring of the isoquinoline framework were easily accessible by a synthetic approach that took advantage of a Sonogashira coupling to build up the C1-C8a bond of the isoquinoline skeleton and a Ti-catalyzed intramol. hydroamination of an alkyne to close the heterocyclic ring.
Heterocycles published new progress about Aliphatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-bromophenyl). 886761-96-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5BrFN, Related Products of 886761-96-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts