Prasad, A. S. G.; Rao, T. Bhaskara; Rambabu, D.; Basaveswara Rao, Mandava V.; Pal, Manojit published the artcile< Ultrasound Assisted Faster and Milder Approach to 6H-pyrido[1,2-a] quinazolin-6-imine Derivatives as Potential Inhibitors of PDE4>, Safety of 3-Chloro-2-fluorobenzonitrile, the main research area is aminopyridine Quinazolinimine pinner reaction bioactive agents potential inhibitor.
Background: The ultrasound assisted methodol. has been explored first time for the quicker synthesis of 6H-pyrido[1,2-a]quinazolin-6-imine derivatives via the reaction of 2-aminopyridines and 2-fluorobenzontriles under mild conditions. Methods: The methodol. is free from the use of any transition metal catalyst and afforded the desired products in good yields. Some of the synthesized compounds were evaluated for their potential PDE4 inhibition in silico and subsequently in vitro. Conclusion: One compound showed dose dependent inhibition of PDE4B and favorable pharmacol. properties indicating potential of this scaffold for the discovery of new inhibitors of PDE4.
Letters in Drug Design & Discovery published new progress about 94087-40-8. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Safety of 3-Chloro-2-fluorobenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts