Park, Yunjeong; Bae, Song Yi; Hah, Jung-Mi; Lee, Sang Kook; Ryu, Jae-Sang published the artcile< Synthesis of stereochemically diverse cyclic analogs of tubulysins>, Recommanded Product: 2,2-Diethoxyacetonitrile, the main research area is tubulysin cyclic analog peptide peptidomimetic enantioselective synthesis thiazole; Diels Alder reaction stereoselective Danishefsky diene type peptide coupling; antitumor agent tubulin polymerization inhibiting structure activity; Antitumor agents; Asymmetric catalysis; Hetero Diels–Alder reaction; Peptides; Tubulysin.
The synthesis of tubulysin analogs containing stereochem. diverse cyclic Tuv moieties is described. A tetrahydropyranyl moiety was incorporated into the Tuv unit by enantioselective hetero Diels-Alder reactions of Danishefsky’s diene and thiazole aldehyde. Four different stereoisomers of cyclic Tuv units were used as surrogates for the Tuv moiety. The synthesized stereochem. diverse simplified cyclic analogs were evaluated for the inhibition of tubulin polymerization
Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Recommanded Product: 2,2-Diethoxyacetonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts