Li, Xiuxiu; You, Cai; Yang, Yusheng; Yang, Yuhong; Li, Pan; Gu, Guoxian; Chung, Lung Wa; Lv, Hui; Zhang, Xumu published the artcile< Rhodium-catalyzed asymmetric hydrogenation of β-cyanocinnamic esters with the assistance of a single hydrogen bond in a precise position>, COA of Formula: C8H5F2N, the main research area is Pregabalin Phenibut Baclofen enantioselective preparation; beta cyano ester enantioselective preparation; cyanocinnamic ester beta asym hydrogenation rhodium catalyst.
With the assistance of hydrogen bonds, the first Rh-catalyzed asym. hydrogenation of β-cyanocinnamic esters R1CNC=CHCO2R2 [R1 = C6H5, 2-FC6H4, 2-naphthyl, etc.; stereo = Z or E] is developed, affording chiral β-cyano esters R1CNCHCHCO2R2 with excellent enantioselectivities (up to 99% ee). This novel methodol. provides an efficient and concise synthetic route to chiral GABA-derivatives such as (S)-Pregabalin, (R)-Phenibut, (R)-Baclofen. Interestingly, in this system, the catalyst with a single H-bond donor performs better than that with double H-bond donors, which is a novel discovery in the metal organocatalysis area.
Chemical Science published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (β-cyano esters). 658-99-1 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H5F2N, COA of Formula: C8H5F2N.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts