Lambert, Kyle M.; Bobbitt, James M.; Eldirany, Sherif A.; Kissane, Liam E.; Sheridan, Rose K.; Stempel, Zachary D.; Sternberg, Francis H.; Bailey, William F. published the artcile< Metal-Free Oxidation of Primary Amines to Nitriles through Coupled Catalytic Cycles>, Recommanded Product: 2,2-Diethoxyacetonitrile, the main research area is primary amine acetamido TEMPO catalyst oxone oxidation; nitrile preparation green chem; amines; catalysis; nitriles; organic chemistry; synthetic methods.
Synergism among several intertwined catalytic cycles allowed for selective, room temperature oxidation of primary amines to the corresponding nitriles in 85-98 % isolated yield. This metal-free, scalable, operationally simple method employed a catalytic quantity of 4-acetamido-TEMPO (ACT; TEMPO = 2,2,6,6-tetramethylpiperidine N-oxide) radical and the inexpensive, environmentally benign triple salt oxone as the terminal oxidant under mild conditions. Simple filtration of the reaction mixture through silica gel afforded pure nitrile products.
Chemistry – A European Journal published new progress about Green chemistry. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Recommanded Product: 2,2-Diethoxyacetonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts