Dmitriev, Viktor; Vedekhina, Tatiana; Sapegin, Alexander; Krasavin, Mikhail published the artcile< Convenient Assembly of Privileged (Hetero)Arene-Fused Benzo[1.4]oxazepines via Two Tandem SNAr Events. Part 3 - (Hetero)arene-Fused benzo[f]imidazo[1,2-d][1,4]oxazepines>, Application of C7H3ClFN, the main research area is heteroarene fused benzo imidazo oxazepine preparation regioselective; aryl imidazole ortho dihalo halonitro arene Smiles rearrangement.
A tandem approach to (hetero)arene-fused benzo[f]imidazo[1,2-d][1,4]oxazepines I (R1 = H, Cl; R2 = H, R1 = R2 = -C4H4-; R3 = H, Me, R2 = R3 = -C4H4-; R4 = CN, NO2, COOMe, etc.; X = C, N, C-CN; Y = C, N) has been described which involves condensation of bis-nucleophilic 2-(2-hydroaryl)imidazoles II with reactivity-matched o-dihalo and o-halonitro (hetero)aromatic substrates III (LG1 = F, Cl; LG2 = F, Cl, Br, NO2). The process is generally regioselective with respect to the unsym. substituted imidazole ring and proceeds via two SNAr events (intermol. first and then intramol.) intermitted by a Smiles rearrangement. In some cases, the last SNAr step provides a rare example of nucleophilic displacement of a nitro group or a halogen in non-activated positions of a (hetero)aromatic ring which does not require the use of a metal catalyst.
ChemistrySelect published new progress about Aromatic nitro compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, Application of C7H3ClFN.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts