Month: September 2022

FitzSimons, Thomas M. team published research on Macromolecules (Washington, DC, United States) in 2020 | 105-34-0

Safety of Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Safety of Methyl 2-cyanoacetate.

FitzSimons, Thomas M.;Oentoro, Felicia;Shanbhag, Tej V.;Anslyn, Eric V.;Rosales, Adrianne M. research published 《 Preferential Control of Forward Reaction Kinetics in Hydrogels Crosslinked with Reversible Conjugate Additions》, the research content is summarized as follows. Mol. substitutions were used to demonstrate preferential control over the kinetic rate constants in a poly(ethylene glycol)-based hydrogel with two different reversible thia-conjugate addition reactions. A strong electron-withdrawing nitrile group on the conjugate acceptor showed a 20-fold increase in the forward rate constant over a neutral withdrawing group, whereas the reverse rate constant only increased 6-fold. Rheometry experiments demonstrated that the hydrogel plateau modulus was primarily dictated by reaction equilibrium, whereas the stress relaxation characteristics of the hydrogel were dominated by the reverse rate constant Furthermore, dynamic crosslinking allowed the hydrogel to rapidly and spontaneously self-heal. These results indicate that decoupling the kinetic rate constants of bond exchange allow systematic control over dynamic covalent hydrogel bulk properties, such as their adaptability, stress relaxation ability, and self-healing properties.

Safety of Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ferreira, Joao Marcos Gomes de Oliveira team published research on Results in Chemistry in 2021 | 105-34-0

SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. SDS of cas: 105-34-0.

Ferreira, Joao Marcos Gomes de Oliveira;da Silva, Girlyanderson Araujo;Coelho, Maisa Cavalcanti;Junior, Claudio Gabriel Lima;Vale, Juliana Alves research published 《 Quick synthesis of isatin-derived Knoevenagel adducts using only eco-friendly solvent》, the research content is summarized as follows. A variety of Knoevenagel compounds I (R1 = H, Me, allyl, Bn; R2 = H, Cl, Br, NO2 , R3 = H, Cl; EWG = CN, COOMe, COOEt) from isatin were synthesized using an eco-friendly methodol. It was used only the binary solvent ethanol: water (3:7 volume/volume) without the presence of metal catalyst what enabled the reaction between different isatins with malononitrile in a quick reaction time of 2-5 min and isolated yields 80-96%. When cyanoesters were used as methylene actives, the reactions were longer and the knoenevagel products were obtained in 79-92% isolated yields.

SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ferlenghi, Francesca team published research on European Journal of Pharmaceutical Sciences in 2020 | 105-34-0

Formula: C4H5NO2, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Formula: C4H5NO2.

Ferlenghi, Francesca;Maccioni, Paola;Mugnaini, Claudia;Brizzi, Antonella;Fara, Federica;Mostallino, Rafaela;Paola, Castelli M.;Colombo, Giancarlo;Mor, Marco;Vacondio, Federica;Corelli, Federico research published 《 The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives》, the research content is summarized as follows. We report an in vitro phase I metabolism study on COR659 (1), a 2-acylaminothiophene derivative able to suppress alc. and chocolate self-administration in rats, likely via pos. allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor. High performance liquid chromatog. coupled to tandem and high resolution mass spectrometry was employed for the characterization of in vitro metabolism and in vivo pharmacokinetics of COR659 in rats. In vitro [35S]GTPγS binding assays on stimulated GABAB and CB1 receptors, in combination with alc. and chocolate self-administration experiments in rats, were employed to assess the pharmacol. profile of this novel set of analogs, using COR659 as reference compound Eight metabolites of COR659 were discovered in liver microsomal incubates; two of them (M1, M2) were identified by comparison with synthetic reference standards In the novel set of COR659 analogs, those bearing branched alkyl substituents on the ester group, showed an improved in vitro metabolic stability (2-4), had an in vitro GABAB PAM (2-4) and/or CB1 partial agonist/antagonist profile (2-3) and maintained the ability to reduce alc. (2-4) and/or chocolate (4) self-administration in rats. Both PK and PD data ruled out any involvement of metabolite M1 in the in vivo potency of COR659 and 4. The present results, therefore, highlight the importance to design and synthesize novel compounds endowed with the dual activity profile and devoid of metabolic liabilities.

Formula: C4H5NO2, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ferdousian, Roghayeh team published research on Molecular Diversity in | 105-34-0

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Computed Properties of 105-34-0

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Computed Properties of 105-34-0.

Ferdousian, Roghayeh;Behbahani, Farahnaz K.;Mohtat, Bita research published 《 Synthesis and characterization of Fe3O4@Sal@Cu as a novel, efficient and heterogeneous catalyst and its application in the synthesis of 2-amino-4H-chromenes》, the research content is summarized as follows. This research paper presents the synthesis and characterization of the magnetic nanoparticle, Fe3O4@Sal@Cu, [Fe3O4@Si-CH2-CH2-CH2-NH-NH-CO-N = CH-(2-HO-C6H4-)@Cu] as a green and retrievable catalyst. This catalyst was characterized by FTIR, XRD, EDX and TGA analyses. In addition, the catalytic activity of this new catalyst was investigated for the synthesis of 2-amino 4H-chromenes by producing good-to-excellent yields under mild reaction conditions. The other advantages of the developed nanocatalyst are its ecofriendliness, being easy to handle, high reusability and being magnetically separable. The synthesis of some new derivatives of 2-amino-4H-chromenes in the presence of this nanocatalyst is also reported.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Computed Properties of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feng, Xiaoquan team published research on AIChE Journal in 2022 | 1835-49-0

Formula: C8F4N2, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Formula: C8F4N2.

Feng, Xiaoquan;Peng, Donglai;Shan, Meixia;Niu, Xinpu;Zhang, Yatao research published 《 Facilitated propylene transport in mixed matrix membranes containing ZIF -8@Agmim core-shell hybrid material》, the research content is summarized as follows. The ZIF-8@Agmim core-shell hybrid material was synthesized via a favorable post-modification method of ion exchange (PMIE). This infrequent ZIF-8@Agmim core-shell structure maintains a well-integrated pore size that is almost the same as ZIF-8. The similar equilibrium isotherms with ZIF-8 and better kinetic separation toward propylene/propane than ZIF-8 render ZIF-8@Agmim to be an interesting candidate for propylene/propane separation The core-shell hybrid nanomaterial was further used as nanofillers in the polymer of intrinsic microporosity matrix (PIM-1) for propylene/propane separation The resultant mixed-matrix membranes (MMMs) exhibited a simultaneous increase in C3H6 permeability and C3H6/C3H8 ideal selectivity compared to pure polymer membrane owing to a synergistic effect of mol. sieving from ZIF-8 and π-complexation of Ag+ with propylene. The separation performance of the prepared MMM surpasses the upper bound line of polymer membranes. Furthermore, the hybrid materials possess superb photochem. stability and the corresponding MMMs exhibit excellent anti-aging property and long-term stability.

Formula: C8F4N2, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fang, Xuerong team published research on Tetrahedron in 2021 | 20099-89-2

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Product Details of C9H6BrNO

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C9H6BrNO.

Fang, Xuerong;Li, Jinsi;Zhong, Qianqian;Ming, Xin research published 《 Synthesis and cytostatic activity of emissive 7-thiazolyl-7-deazapurine nucleosides》, the research content is summarized as follows. 7-Functionalized 7-deazapurine fluorescent nucleosides are highly important for biotechnol. applications. Here, 7-substituted 7-deaza-2′-deoxyguanosines, e.g. I, comprising a 4H-cyclopenta[d]thiazole ring are obtained by Hantzsch synthesis reaction of 7-thioamide-7-deaza-2′-deoxyguanosine with aromatic α-bromocarbonyl compounds (61-85%). Their photophys. properties are determined by UV and fluorescence spectroscopy, and the cytostatic activities are evaluated by MTT assay. All compounds exhibit strong solvatochromicity and pH-dependent fluorescence in aqueous solutions, indicating their promising ability to be fluorescent probes. The 7-substituted 7-deaza-2′-deoxyguanosines, e.g. I, exert cytostatic activities, which means they have the potential to be candidate for theranostics.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Product Details of C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fang, Fang team published research on Journal of Organic Chemistry in 2022 | 3032-92-6

COA of Formula: C9H5N, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. COA of Formula: C9H5N.

Fang, Fang;Zheng, Haolin;Mao, Guojiang;Chen, Shanping;Deng, Guo-Jun research published 《 Metal- and Solvent-Free Synthesis of Tetrahydrobenzo[c]carbazolones through NaI-Catalyzed Formal [4+2] Annulation》, the research content is summarized as follows. A novel strategy for the preparation of functional carbazoles through NaI-catalyzed formal [4+2] annulation of 2-(indol-3-yl)cyclohexanones and alkynes/alkenes was developed. The present approach started from easily available raw materials and provided a variety of tetrahydrobenzo[c]carbazolones in satisfactory yields under metal- and solvent-free conditions. The products could be further transformed into structurally valuable carbazole-based conjugated derivatives

COA of Formula: C9H5N, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Zhe team published research on Journal of Organic Chemistry in | 3032-92-6

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Name: 4-Ethynylbenzonitrile

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Name: 4-Ethynylbenzonitrile.

Fan, Zhe;Ni, Shao-Fei;Pang, Jin-Yu;Guo, Li-Ting;Yang, Hao;Li, Ke;Ma, Cheng;Liu, Ji-Kai;Wu, Bin;Yang, Jin-Ming research published 《 Cu(I)-Catalyzed Cross-Coupling Rearrangements of Terminal Alkynes with Tropylium Tetrafluoroborate: Facile Access to Barbaralyl-Substituted Allenyl Acid Esters and 7-Alkynyl Cycloheptatrienes》, the research content is summarized as follows. Herein, a novel strategy for the formation of copper carbene via the cycloisomerization of the π-alkyne-Cu(I) complex from terminal alkynes RCCH [R = MeOC(O), BnOC(O), Ph, 1-naphthyl, 3-thienyl, etc.] and tropylium tetrafluoroborate was reported. Mechanistic studies and DFT calculations indicate that the reaction undergoes the intramol. cycloisomerization process from the π-alkyne-Cu(I) complex to afford the copper carbene intermediate, followed by migratory insertion with the second terminal alkyne to afford the barbaralyl-substituted allenyl acid esters I. In addition, a mild and highly efficient Cu(I)-catalyzed cross-coupling protocol to synthesize 7-alkynyl cycloheptatrienes II that has a broad functional group tolerance is developed and it is applicable to the late-stage functionalization of natural products.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Name: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Shu-Ting team published research on Separation and Purification Technology in 2022 | 1835-49-0

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Reference of 1835-49-0

Nitrile is any organic compound with a −C≡N functional group. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Reference of 1835-49-0.

Fan, Shu-Ting;Tan, Min;Liu, Wen-Tao;Li, Bang-Jing;Zhang, Sheng research published 《 MOF-layer composite polyurethane membrane increasing both selectivity and permeability: Pushing commercial rubbery polymer membranes to be attractive for CO2 separation》, the research content is summarized as follows. We demonstrated a novel MOF-layer composite membrane consisting of three layers, based on a polyurethane/PIM layer and a UiO-66-NH2 layer to sep. CO2/N2 mixture A small amount of PIM (i.e., ≤10 wt% PIM in PU) could completely dissolve in PU. After blending it with PU, it could use its own porosity to increase the CO2 permeability of the PU/PIM polymer blend layer. UIO66-NH2 was prepared into a 10μm thick MOF layer by spin coating. The densely packed MOF in this layer brings abundant adsorption sites to enrich CO2, thereby bringing high selectivity to the composite film. These unique two layers simultaneously increase permeability and CO2/N2 selectivity, and the PAN-UIO66-NH2-PU/PIM (10 wt%) composite membrane displayed a CO2 permeance of 333 Barrer and a CO2/N2 selectivity of 138, its performance can easily exceed the 2008 CO2/N2 upper bound. Moreover, the entanglement of its mol. chain with PIM slows down the aging, leading a more consistent selectivity performance over a sixty-day-ageing study period. This attractive separation performance of PAN-UIO66-NH2-PU/PIM provides an exciting platform for rubbery polymer membranes to economically sep. CO2 and makes com. PU an attractive option for large-scale industrial CO2 separation

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Reference of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Junmei team published research on Sensors and Actuators, B: Chemical in 2021 | 1835-49-0

HPLC of Formula: 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. HPLC of Formula: 1835-49-0.

Fan, Junmei;Qi, Lu;Qiao, Min;Gao, Zhipeng;Ding, Liping;Fang, Yu research published 《 A simple sensor ensemble-based chemical tongue for powerful fingerprint identification of multiple thiols and juice powder》, the research content is summarized as follows. A powerful discriminative sensor for identifying different thiols and their mixtures was developed. The sensor was easily constructed by using surfactant CTAB assemblies encapsulating two com. available fluorophores, namely, tetrafluoroterephthalonitrile (4F-2CN) and rhodamine B (RhB). UV-vis absorption and ESI-MS measurements revealed 4F-2CN can react with different thiols and yields different products with diverse absorption behaviors. Fluorescence measurements and control experiments showed that this single-system based sensor exhibits typical multiple-wavelength cross-reactive responses to multiple thiols, and RhB plays an important role in the process. This single sensor platform can not only distinguish 8 structurally similar thiols, but also differentiate their mixtures and be applied for identifying various com. juice powder of different brands or tastes and even com. available liquid juice of different tastes.

HPLC of Formula: 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts