Month: September 2022

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Name: 4-Nitrophthalonitrile.

Hu, Jianghuai;Xie, Huanxin;Zhu, Zhengzhu;Yang, Wenjie;Tan, Wei;Zeng, Ke;Yang, Gang research published 《 Reducing the melting point and curing temperature of aromatic cyano-based resins simultaneously through a Bronsted acid-base synergistic strategy》, the research content is summarized as follows. High m.ps. (M_p) and high curing temperatures are two key processing problems that limit the application of aromatic cyano-based (AC) resins. A Bronsted acid-base synergistic strategy based on an acid-base eutectic and mechanisms for nucleophilic addition and ionization equilibrium are proposed to reduce the M_p and curing temperature of AC resins. Blends of 4,5-dicyanoimidazole (DCI, Bronsted acid) and amine-containing phthalonitriles (4 or 2 or 3)-aminophenoxy phthalonitrile, APNs, Bronsted bases were selected as model acid-base systems to study the synergistic behaviors in processing. The results show that the M_p and the peak exothermic temperature (T_rp) of APN-DCI blends can be reduced by more than 31°C and 85°C compared with their intrinsic components, resp. DSC and XRD show that the decrease in the Mp of the blends is induced by the formation of eutectics. A pos. relationship between pKa and the curing reactivity is confirmed by theory and exptl. methods. The cured products show outstanding thermal and mech. properties compared with reported AC resins. This research provides a new convenient route for regulating the curing behavior of AC resins and will significantly promote the development of high-performance AC resins.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Name: 4-Nitrophthalonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Application In Synthesis of 3032-92-6.

Hu, Guo-Qin;Yao, Li-Wei;Gui, Shu-Sheng;Geng, Chuang;Zhang, Wen-Yan;Liu, Jing-Hui;Zhao, Bin research published 《 Copper-Catalyzed Cross-Coupling of Arylacetylenes with Bromodifluoroacetamides》, the research content is summarized as follows. A copper-catalyzed radical difluoroalkylation of arylacetylenes with bromodifluoroamides has been developed. The reaction exhibits good functional group tolerance and allows access to a variety of substituted α-alkynyl-α,α-difluoroacetamides in moderate to good yields. The potential for scale-up reaction and products derivatization also makes this method attractive for practical applications. Preliminary mechanistic studies suggest that a radical reaction pathway might be involved in the catalytic system.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Application In Synthesis of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Product Details of C9H5N.

Hu, Guo-Qin;Wang, Cai;Zhao, Fan;Liu, Yao-Wei;Liu, Jing-Hui;Zhao, Bin research published 《 Copper-Catalyzed of Terminal Alkynes with N-Thiosuccinimides to Access Alkynyl Sulfides》, the research content is summarized as follows. Copper-catalyzed thiolation of terminal alkynes with N-thiosuccinimides was developed. The reaction demonstrated an expanded substrate scope and produced various alkynyl sulfides I [R¹ = 4-MeC₆H₄, 4-MeOC(O)C₆H₄, 2-pyridyl, etc.; R² = CH₃, C₆H₅, 4-FC₆H₄, etc.] in moderate to good yields. Gram-scale synthesis and further transformations confirmed the synthetic utility of this methodol. Mechanistic studies revealed that a Cu(I)/Cu(III) catalytic cycle was probably involved in the process of alkynylthiolation.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Product Details of C9H5N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-Ethynylbenzonitrile.

Hruzd, Mariia;le Poul, Nicolas;Cordier, Marie;Kahlal, Samia;Saillard, Jean-Yves;Achelle, Sylvain;Gauthier, Sebastien;Robin-le Guen, Francoise research published 《 Luminescent cyclometalated alkynylplatinum(II) complexes with 1,3-di(pyrimidin-2-yl)benzene ligands: synthesis, electrochemistry, photophysics and computational studies》, the research content is summarized as follows. In this article, we report on a series of cyclometalated chloro- and alkynyl-platinum(II) complexes [(Pym₂C₆H₂R)PtX] (1–14; Pym = 2-pyrimidinyl-κN; R = H, OMe, CF₃; X = Cl, CCC₆H₄Y, with Y = H, OMe, CN, CHO, NPh₂) bearing various tridentate N-C-N-cyclometalated ligands derived from 1,3-bis(pyrimidin-2-yl)benzene. The X-ray crystal structures of two alkynyl-platinum(II) complexes were determined and other structures were DFT-calculated Electrochem. and DFT-computational studies suggest a ligand-centered reduction on the R¹-substituted N-C-N ligand, whereas oxidation likely occurs either on the Pt-phenylacetylide moiety and/or the cyclometalated ligand. In CH₂Cl₂ solution at room temperature, the complexes show phosphorescent emissions ranging from green to orange, depending on the R¹ and R² substituents on the ligands. In KBr solid state matrix, excluding complexes bearing a trifluoromethyl substituted ligand, all compounds exhibit red emission. The presence of an alkynyl ancillary ligand has limited influence on absorption and emission spectra except in the case of the complex with the strongly electron-donating diphenylamino R² substituent on the alkynyl ligand, for which a significant red-shift was observed The alkynyl Pt(II) complex with OMe groups as both R¹ and R² substituents shows the best emission quantum yield (0.81 in CH₂Cl₂ solution) in this series. The full series of DFT calculated band gaps correlated generally well with the electrochem. and absorption data and reasonably model the impact of the substituents on the electronics of these complexes.

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. HPLC of Formula: 3032-92-6.

Hou, Zhong-Wei;Li, Laiqiang;Wang, Lei research published 《 Regio- and stereoselective electrochemical selenoalkylation of alkynes with 1,3-dicarbonyl compounds and diselenides》, the research content is summarized as follows. A regio- and stereoselective electrochem. approach for the seleno(monofluoro)alkylation of alkynes with 1,3-dicarbonyl compounds and diselenides has been developed. The electrosynthesis method utilizes C-H substrates as radical precursors and the source of carbon atoms, avoiding dependence on pre-functionalized substrates. A series of selenated alkenes, e.g., I, were prepared with satisfactory outcomes under noble metal-free and oxidizing reagent-free conditions.

HPLC of Formula: 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Related Products of 1835-49-0.

Hou, Rujing;Smith, Stefan J. D.;Konstas, Kristina;Doherty, Cara M.;Easton, Christopher D.;Park, Jaesung;Yoon, Heewook;Wang, Huanting;Freeman, Benny D.;Hill, Matthew R. research published 《 Synergistically improved PIM-1 membrane gas separation performance by PAF-1 incorporation and UV irradiation》, the research content is summarized as follows. Super-glassy polymer membranes have suffered from the trade-off relationship between permeability and selectivity for gas separation applications, despite the fact that membrane technol. exhibits remarkable energy efficiency advantages over other separation methods. Polymers of intrinsic microporosity such as PIM-1 offer high fractional free volume (FFV) and intermediate gas selectivity, with permeability several orders of magnitude higher than conventional glassy polymers. The methods of producing mixed matrix membranes (MMM) by incorporating nanoparticles into a polymer matrix, or crosslinking, have been widely studied to improve membrane selectivity. While crosslinking and nanoparticle incorporation often increase selectivity or permeability, resp., this is typically at the expense of the other, limiting transport properties to the Robeson upper bound. Porous aromatic frameworks such as PAF-1 have been shown to significantly increase the permeability of PIM membranes. Here, this nanoparticle additive is coupled with post UV irradiation treatment resulting in a membrane with both significantly improved membrane selectivity (i.e., 16-fold improvement for H₂/CH₄ selectivity, from 5.4 to 90) and high permeability (i.e., P(H₂) = 4800 Barrer). Characterization of the dual-enhanced membrane revealed that the synergetic performance is caused by a combination of the selective skin layer formed upon UV photo-oxidation with the addnl. permeable gas transport channels introduced to the bulk matrix by PAF-1. As a result of this dual-approach to membrane enhancement, the PIM-1 MMM exhibited better gas separation performance, surpassing the 2015 upper bounds for H₂/N₂ and H₂/CH₄ as well as 2008 upper bounds for H₂/CO₂ and CO₂/CH₄. Aging studies confirmed that PAF-1 addition, UV irradiation, and both modifications slowed phys. aging rate compared to the pure PIM-1 membrane. The performance of this membrane was also investigated at a range of thicknesses, revealing its potential as a candidate for other membrane forms at scale.

Related Products of 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. SDS of cas: 105-34-0.

Hood, Jacob C.;Tshikaya, Yannick;Manz, Aaren R.;LaPorte, Marcus C.;Klumpp, Douglas A. research published 《 Double Addition Reactions Involving Vinyl-Substituted N-Heterocycles and Active Methylene Compounds》, the research content is summarized as follows. A series of conjugate addition reactions was performed with vinyl-substituted N-heterocycles with active methylene compounds such as 1,3-dicarbonyl compounds, cyano esters, a cyano sulfone and malonyl nitrile to provide dipyridyl and related heterocyclic products I [R¹ = R² = H, (pyridin-4-yl)ethyl, (pyridin-2-yl)ethyl, (pyrazin-2-yl)ethyl, (quinolin-2-yl)ethyl, (quinoxalin-2-yl)ethyl; n = 0, 1; X = O, CH₂, NMe; R¹ = H, Me, R² = H, Ph, 4-(Me)₂NC₆H₄, etc.] in acid-catalyzed conversions. The Michael accepting groups included vinyl-substituted pyridines, quinoline, and pyrazine. Double conjugate addition reactions was accomplished with 2,6-divinylpyridine and related systems.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., SDS of cas: 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. SDS of cas: 20099-89-2.

Hebade, Madhav J.;Deshmukh, Tejshri R.;Dhumal, Sambhaji T. research published 《 Silica supported dodecatungstophosphoric acid (DTP/SiO₂): An efficient and recyclable heterogeneous catalyst for rapid synthesis of quinoxalines》, the research content is summarized as follows. A facile synthesis of quinoxalines by the cyclocondensation of substituted phenacyl bromides with o-pheneylenediamines using silica-supported dodecatungstophosphoric acid (DTP/SiO₂) as a recyclable heterogeneous catalyst is unveiled in this research work. This method is practicable due to environmentally benign, easy workup, high yield, less reaction time, low cost, mild reaction condition, and recyclable heterogeneous catalyst. The catalyst can be easily recovered from the reaction mixture only by filtration and reused up to five catalytic cycles without significant loss of catalytic activity and product yield. This leads to making the process more affordable.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., SDS of cas: 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Recommanded Product: 4-(2-Bromoacetyl)benzonitrile.

He, Xinwei;Li, Ruxue;Choy, Pui Ying;Liu, Tianyi;Wang, Junya;Yuen, On Ying;Leung, Man Pan;Shang, Yongjia;Kwong, Fuk Yee research published 《 DMAP-Catalyzed Annulation Approach for Modular Assembly of Furan-Fused Chromenes》, the research content is summarized as follows. With a tandem DMAP-catalyzed reaction between o-AQM, in which it is generated in situ from propargylic amine, and acyl carbene surrogate (from pyridinium ylide), a variety of polyarylated chromenes are assembled in good yields. This process does not require transition-metal catalyst and exhibits easy manipulation of the arene group and good functional group compatibility, particularly the -Br group which can be further transformed to other functionalities by cross-coupling reactions. The modular feature of o-AQM substrates and the simple operation procedures add further advantages to this synthetic method.

Recommanded Product: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Reference of 3032-92-6.

He, Xin;Kuang, Shuang;Gao, Qian;Xie, YuXin;Ming, Xin research published 《 Bright fluorescent purine analogues as promising probes》, the research content is summarized as follows. Modified bright fluorescent nucleosides that respond to the micro-environment have great potential as probes. A series of novel 8-(phenylethynyl)phenylated 2-amino-2′-deoxyadenosine and 2′-deoxyisoguanosine derivatives have been synthesized by Sonogashira-type coupling reaction and Suzuki reaction. The maximum emission of the new compounds is in the visible region, with strong solvatochromicity and pH-dependent fluorescent properties. Furthermore, some of them exhibit bright fluorescence emissions in various solvents (ε x Φ = 4000-39,000 cm^-1 M^-1). These consequences indicate that purine analogs could respond to the microenvironment and serve as promising fluorescent probes.

Reference of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts