Month: September 2022

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Category: nitriles-buliding-blocks.

Demirbas, Umit;Ozturk, Dilek;Akcay, Hakki Turker;Durmus, Mahmut;Mentese, Emre;Kantekin, Halit research published 《 Metallo-phthalocyanines containing triazole substituents: Synthesis, spectroscopic and photophysicochemical properties》, the research content is summarized as follows. Magnesium(II) (4), lead(II) (5) and zinc(II) (6) phthalocyanines were prepared The structures of 4–6 were confirmed by the spectroscopic characterization such as FTIR, ¹H-NMR, MALDI-TOF mass, UV-visible and fluorescence spectral data. The aggregation behavior of the triazole substituted phthalocyanines (4–6) was studied in different solvents and no aggregation was observed The photophysicochem. properties of 4–6 were studied in DMSO. The photophys. and photochem. behaviors varied depending on the type of metal in the center of phthalocyanine. The zinc(II) phthalocyanine 6 showed the highest singlet oxygen quantum yield and the highest photostability. The magnesium(II) phthalocyanine 4 exhibited the highest fluorescence quantum yield. The zinc(II) phthalocyanine 6 has good photosensitizer performance due to its high singlet oxygen generation ability, high photostability and formation of non-aggregated species.

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Reference of 20099-89-2.

Fultariya, Chirag R.;Harsora, Jalpa P. research published 《 Synthesis, antimicrobial activity and cytotoxicity of 2-substituted benzimidazole incorporated with thiazole》, the research content is summarized as follows. Two new series 2-(2-(1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylidene)hydrazinyl)-4-(aryl)thiazoles I (R = H, 4-CH₃, 2-Cl, etc.) and 2-(2-(1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethyl)hydrazinyl)-4-(aryl)thiazoles II (R =H, 4-CH₃, 2-Cl, etc.) encompassing benzimidazole incorporated with thiazole have been synthesized using rational approach. These thiazole derivatives I have been reduced at the site of formation of Schiff base (>CH = N0) to obtain final compounds II. Compounds I and II have been screened for their in vitro antibacterial and antifungal actions against four strains each. Among the screened compounds, I (R = 2-Cl, 4-Cl, 4-Br, 4-F, 2,4-diCl, 2,4-diF) and II (R = 2-Cl, 4-Cl, 4-Br, 2,4-diF) have emerged as highly effective antibacterial agents, while compounds I (R = 2-Cl, 4-Cl, 4-Br, 2,4-diF) and II (R = 2,4-diF) have come out as most potent antifungal mols. Comparison of outcomes of antibacterial and antifungal screening of compounds I and II directed that antimicrobial potential of unreduced derivatives I is higher than reduced derivatives II. SAR study reveals that presence of halogen (-F, -Cl, -Br) substituents is accountable for significant antimicrobial potential. Also the results of preliminary MTT cytotoxicity assay on HeLa cells indicates that antimicrobial activity of I (R = 4-Cl, 4-Br, 4-F, 2,4-diCl, 2,4-diF) and II (R = 4-Cl, 4-Br, 2,4-diF) is accompanied by low extent of cytotoxic concentrations

Reference of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts