Month: September 2022

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Recommanded Product: Tetrafluoroterephthalonitrile.

Contreras-Martinez, Jorge;Mohsenpour, Sajjad;Ameen, Ahmed W.;Budd, Peter M.;Garcia-Payo, Carmen;Khayet, Mohamed;Gorgojo, Patricia research published 《 High-Flux Thin Film Composite PIM-1 Membranes for Butanol Recovery: Experimental Study and Process Simulations》, the research content is summarized as follows. Thin film composite (TFC) membranes of the prototypical polymer of intrinsic microporosity (PIM-1) have been prepared by dip-coating on a highly porous electrospun polyvinylidene fluoride (PVDF) nanofibrous support. Prior to coating, the support was impregnated in a non-solvent to avoid the penetration of PIM-1 inside the PVDF network. Different non-solvents were considered and the results were compared with those of the dry support. When applied for the separation of n-butanol/water mixtures by pervaporation (PV), the developed membranes exhibited very high permeate fluxes, in the range of 16.1-35.4 kg m^-2 h^-1, with an acceptable n-butanol/water separation factor of about 8. The PV separation index (PSI) of the prepared membranes is around 115, which is among the highest PSI values that have been reported so far. Hybrid PV-distillation systems have been designed and modeled in Aspen HYSYS using Aspen Custom Modeler for setting up the PIM-1 TFC and com. PDMS membranes as a benchmark. The butanol recovery cost for the hybrid systems is compared with a conventional stand-alone distillation process used for n-butanol/water separation, and a 10% reduction in recovery cost was obtained.

Recommanded Product: Tetrafluoroterephthalonitrile, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Quality Control of 31643-49-9.

Cong, Fangdi;Jiang, Hongzhen;Du, Xiguang;Yang, Wei;Zhang, Shulin research published 《 Facile, Mild-Temperature Synthesis of Metal-Free Phthalocyanines》, the research content is summarized as follows. It is important for the synthesis and research of phthalocyanine compounds for these compounds to be easily obtained at low temperature It was observed that metal-free phthalocyanine was sometimes found in a simple system used to synthesize phthalocyanine precursors at room temperature, and further studies showed that the key to the effective formation of phthalocyanines at low temperature lay in the presence of equal volumes of alc. and amine, in addition to substrate phthalonitriles and solvents, in the reaction system. A synthetic mechanism was proposed and facile syntheses have been realized, such as the synthesis of tetra-α(β)-nitrophthalocyanines and tetra-α(β)-(4- tert-butylphenoxy)phthalocyanines from the corresponding substituted phthalonitriles at mild temperature (37°C). The results are significant for the design and synthesis of new phthalocyanine derivatives, and the method is convenient and easy to adopt for general use in standard laboratories

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Quality Control of 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Reference of 3032-92-6.

Cleemann, Felix;Kum-Cheung, Wendy Loa;Karuso, Peter research published 《 Combinatorial synthesis of new fluorescent scaffolds using click chemistry》, the research content is summarized as follows. Azides and acetylenes are bio-orthogonal functional groups that can be readily coupled using copper(I)- or ruthenium(II)- catalyzed 1,3-dipolar cycloaddition reactions. Using non-fluorescent aromatic azides and aromatic acetylenes, covering a range of electron rich and poor building blocks, the Huisgen cycloaddition afford 1,4-disubstituted or 1,5-disubstituted 1,2,3-triazoles. Using a combinatorial approach by running reaction in parallel in polypropylene 96-well plates we discovered several new fluorescent 1,2,3-triazoles scaffolds. These compounds show diverse interactions with biomols. that could find applications in biol. in, for example, fluorescence microscopy or biomol. quantification.

Reference of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Category: nitriles-buliding-blocks.

Choi, Sang-Kee;Lee, Youngjun;Yoon, Sang Eun;Choi, Hongseo;Kim, Jonghoon;Kim, Jong H.;Lee, Sanghee;Kim, Wook;Kim, Eunha research published 《 A tetrazine-fused aggregation induced emission luminogen for bioorthogonal fluorogenic bioprobe》, the research content is summarized as follows. Bioorthogonal fluorogenic probes allow spatiotemporally controlled mol. bioimaging with minimal perturbation of the native cellular environment. Due to favorable kinetics and reaction specificity in a physiol. environment, inverse electron-demand Diels – Alder reaction (iEDDA) for bioorthogonal fluorogenic bioimaging has gained immense attention in scientific field; however, the technique still needs to washout excess trans-cyclooctene labels, thereby reducing the robustness and exptl. convenience. In the present study, we report tetrazine-modified aggregation-induced emission luminogens for bioorthogonal fluorogenic bioimaging. We found that a unique mol. design strategy allowed incorporation of tetrazine on aggregation-induced emission luminogens with excellent fluorogenic properties. Moreover, tetrazine modification of aggregation-induced emission luminogens results in non-radiative decay, which induces fluorescence quenching. The systematic tunability of the emission wavelength of the fluorescent core skeleton allowed successful development of three different colorful fluorogenic tetrazine-fluorophores. Furthermore, an aggregate formation study and computational calculations revealed a synergistic fluorescent quenching effect between intramol. charge transfer and tetrazine-mediated non-radiative decay. The final simple conjugation between triphenylphosphonium and tetrazine-fluorophore enabled successful development of fluorogenic probes for spatiotemporally controlled bioorthogonal bioimaging of mitochondria in live cells with the iEDDA without washing the trans-cyclooctene label and tetrazine-fluorophore.

Category: nitriles-buliding-blocks, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Electric Literature of 105-34-0.

Chinta, Bhavani Shankar;Arora, Sahil;Hoye, Thomas R. research published 《 Trapping Reactions of Benzynes Initiated by Intramolecular Nucleophilic Addition of a Carbonyl Oxygen to the Electrophilic Aryne》, the research content is summarized as follows. We describe here reactions in which a carbonyl oxygen atom initiates cascade reactions by nucleophilic attack on a covalently attached benzyne. The benzynes are produced by thermal cyclization of triynes via hexadehydro-Diels-Alder reaction. The initially produced oxocarbenium/aryl carbanionic zwitterion is protonated in situ by an external protic nucleophile (NuH) of appropriate acidity. The resulting ion pair (oxocarbenium⁺/Nu^–) collapses through several different mechanistic manifolds, adding to the diversity of structural classes that can be generated.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Electric Literature of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. HPLC of Formula: 105-34-0.

Chesman, Anthony S. R.;Liepa, Andris J. research published 《 Some Products from C=O Condensations of Quinacridones》, the research content is summarized as follows. Quinacridone chem. has been developed which provides a source of new compounds that have potential application in organic photovoltaic (OPV) devices. Phosphoryl chloride is used for the conversion of carbonyl groups in N,N’-dialkylquinacridones, generating reactive intermediates that enable selective condensation with either one or two nucleophilic mols. under mild conditions. Thus, e.g., treatment of 5,12-dioctylquinacridone with Me cyanoacetate in presence of POCl₃ afforded I (74%).

HPLC of Formula: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Synthetic Route of 105-34-0.

Cheng, Peter T. W.;Kaltenbach, Robert F.;Zhang, Hao;Shi, Jun;Tao, Shiwei;Li, Jun;Kennedy, Lawrence J.;Walker, Steven J.;Shi, Yan;Wang, Ying;Dhanusu, Suresh;Reddigunta, Ramesh;Kumaravel, Selvakumar;Jusuf, Sutjano;Smith, Daniel;Krishnananthan, Subramaniam;Li, Jianqing;Wang, Tao;Heiry, Rebekah;Sum, Chi Shing;Kalinowski, Stephen S.;Hung, Chen-Pin;Chu, Ching-Hsuen;Azzara, Anthony V.;Ziegler, Milinda;Burns, Lisa;Zinker, Bradley A.;Boehm, Stephanie;Taylor, Joseph;Sapuppo, Julia;Mosure, Kathy;Everlof, Gerry;Guarino, Victor;Zhang, Lisa;Yang, Yanou;Ruan, Qian;Xu, Carrie;Apedo, Atsu;Traeger, Sarah C.;Cvijic, Mary Ellen;Lentz, Kimberley A.;Tirucherai, Giridhar;Sivaraman, Lakshmi;Robl, Jeffrey;Ellsworth, Bruce A.;Rosen, Glenn;Gordon, David A.;Soars, Matthew G.;Gill, Michael;Murphy, Brian J. research published 《 Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA₁) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases》, the research content is summarized as follows. The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA₁) antagonist, with a human LPA₁K_b of 6.9 nM. The structure-activity relationship (SAR) studies starting from the LPA₁ antagonist clin. compound BMS-986020 (1), which culminated in the discovery of 33, are discussed. The detailed in vitro and in vivo preclin. pharmacol. profiles of 33, as well as its pharmacokinetics/metabolism profile, are described. On the basis of its in vivo efficacy in rodent chronic lung fibrosis models and excellent overall ADME (absorption, distribution, metabolism, excretion) properties in multiple preclin. species, 33 was advanced into clin. trials, including an ongoing Phase 2 clin. trial in patients with lung fibrosis (NCT04308681).

Synthetic Route of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Computed Properties of 1835-49-0.

Cheng, Gong;Zhang, Anrui;Zhao, Zhiwei;Chai, Zimin;Hu, Baowei;Han, Bing;Ai, Yuejie;Wang, Xiangke research published 《 Extremely stable amidoxime functionalized covalent organic frameworks for uranium extraction from seawater with high efficiency and selectivity》, the research content is summarized as follows. Uranium extraction from seawater is of strategic significance for nuclear power generation. Amidoxime-based functional adsorbents play indispensable roles in the recovery of seawater uranium with high efficiency. Nevertheless, balancing the adsorption capacity and selectivity is challenging in the presence of complicated interfering ions especially vanadium. Herein, a polyarylether-based covalent organic framework functionalized with open-chain amidoxime (COF-HHTF-AO) was synthesized with remarkable chem. stability and excellent crystallinity. Impressively, the adsorption capacity of COF-HHTF-AO towards uranium in natural seawater reached up to 5.12 mg/g, which is 1.61 times higher than that for vanadium. Detailed computational calculations revealed that the higher selectivity for uranium over vanadium originated from the specific bonding nature and coordination pattern with amidoxime. Combining enhanced adsorption capacity, excellent selectivity and ultrahigh stability, COF-HHTF-AO serves as a promising adsorbent for uranium extraction from the natural seawater.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Computed Properties of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Name: 4-Nitrophthalonitrile.

Chen, Zhongxin;Song, Jingting;Zhang, Rongrong;Li, Runlai;Hu, Qikun;Wei, Pingping;Xi, Shibo;Zhou, Xin;Nguyen, Phuc T. T.;Duong, Hai M.;Lee, Poh Seng;Zhao, Xiaoxu;Koh, Ming Joo;Yan, Ning;Loh, Kian Ping research published 《 Addressing the quantitative conversion bottleneck in single-atom catalysis》, the research content is summarized as follows. Single-atom catalysts (SACs) offer many advantages, such as atom economy and high chemoselectivity; however, their practical application in liquid-phase heterogeneous catalysis is hampered by the productivity bottleneck as well as catalyst leaching. Flow chem. is a well-established method to increase the conversion rate of catalytic processes, however, SAC-catalyzed flow chem. in packed-bed type flow reactor is disadvantaged by low turnover number and poor stability. In this study, we demonstrate the use of fuel cell-type flow stacks enabled exceptionally high quant. conversion in single atom-catalyzed reactions, as exemplified by the use of Pt SAC-on-MoS₂/graphite felt catalysts incorporated in flow cell. A turnover frequency of approx. 8000 h^-1 that corresponds to an aniline productivity of 5.8 g h^-1 is achieved with a bench-top flow module (nominal reservoir volume of 1 cm³), with a Pt₁-MoS₂ catalyst loading of 1.5 g (3.2 mg of Pt). X-ray absorption fine structure spectroscopy combined with d. functional theory calculations provide insights into stability and reactivity of single atom Pt supported in a pyramidal fashion on MoS₂. Our study highlights the quant. conversion bottleneck in SAC-mediated fine chems. production can be overcome using flow chem.

Name: 4-Nitrophthalonitrile, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Application of C4H5NO2.

Chen, Zhipeng;Zhang, Lina;Yang, Junjie;Zheng, Lu;Hu, Fanjie;Duan, Siqin;Nandakumar, Kutty Selva;Liu, Shuwen;Yin, Hang;Cheng, Kui research published 《 Design, Synthesis, and Structure-Activity Relationship of N-Aryl-N’-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy》, the research content is summarized as follows. Herein, the chem. optimization of initial hit, 1-phenyl-3-(thiophen-2-yl)urea, which resulted in the identification of SMU-C80 I (V) (EC₅₀ = 31.02 ± 1.01 nM) as a TLR2-specific agonist with a 370-fold improvement in bioactivity was presented. Mechanistic studies revealed that SMU-C80 (V), through TLR1/2, recruits the adaptor protein MyD88 and triggers the NF-κB pathway to release cytokines such as TNF-α and IL-1βfrom human, but not murine, cells. To the best of the knowledge, it is the first species-specific TLR1/2 agonist reported until now. Moreover, SMU-C80 (V) increased the percentage of T, B, and NK cells ex vivo and activated the immune cells, which suppressed cancer cell growth in vitro. In summary, a highly efficient and specific human TLR1/2 agonist II (R¹ = H, Et, iso-Pr, phenylethyl, etc.; R² = 4-fluorophenyl, naphth-1-yl, 4-bromonaphth-1-yl, etc.; n = 1-3; Y = O, S), III (R³ = H, phenyl) and IV (X = CH, N) that acts through the MyD88 and NF-κB pathway, facilitating cytokine release and the simultaneous activation of immune cells that in turn affects the apoptosis of cancer cells was obtained.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Application of C4H5NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts