Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Name: Methyl 2-cyanoacetate.
Irfan, Majeed;Deng, Rong;Sumra, Idrees;Zhu, Xiao-Feng;Liu, Tingting;Zeng, Zhuo research published 《 Stereoselective synthesis of E, E / E, Z isomers based on 1-(4- iodophenyl)-2,5-divinyl-1H-pyrrole core skeleton: A configuration-controlled fluorescence characteristics and highly selective anti-cancer activity》, the research content is summarized as follows. The E and Z isomeric intermediates based on ethyl/methyl-2-cyano-3-(5-formyl-1-(4-iodo-phenyl)-1H-pyrrol-2-yl)acrylate was synthesized and these intermediates (E or Z) were further stereo-selectively converted into their resp. E, E or E, Z isomers of diethyl/dimethyl-3,3′-(1-(4-iodophenyl)-1H-pyrrole-2,5-diyl)bis (2-cyanoacrylate) at the first time. The E, E isomers of both diethyl-3,3′-(1-(4-iodophenyl)-1H-pyrrole-2,5-diyl)(2E,2’E)-bis(2-cyanoacrylate) and dimethyl-3,3′-(1-(4-iodophenyl)-1H-pyrrole-2,5-diyl)(2E,2’E)-bis(2-cyanoacrylate), in solid state displayed higher quantum efficiency with longer fluorescent lifetime as compared to E, Z isomers. Notably, the E, E isomers proved to be better AIEs while, E, Z isomer of Et (Z)-2-cyano-3-(5-((E)-2-cyano-3-ethoxy-3-oxoprop-1-en-1-yl)-1-(4-iodophenyl) -1H-pyrrol-2-yl)acrylate was eminent anticancer activity against human nasopharyngeal carcinoma. A simple and straight forward strategy was firstly developed to utilize the impact of configuration on fluorescence and anti-cancer activity.
Name: Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts