Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. SDS of cas: 105-34-0.
Hood, Jacob C.;Tshikaya, Yannick;Manz, Aaren R.;LaPorte, Marcus C.;Klumpp, Douglas A. research published 《 Double Addition Reactions Involving Vinyl-Substituted N-Heterocycles and Active Methylene Compounds》, the research content is summarized as follows. A series of conjugate addition reactions was performed with vinyl-substituted N-heterocycles with active methylene compounds such as 1,3-dicarbonyl compounds, cyano esters, a cyano sulfone and malonyl nitrile to provide dipyridyl and related heterocyclic products I [R1 = R2 = H, (pyridin-4-yl)ethyl, (pyridin-2-yl)ethyl, (pyrazin-2-yl)ethyl, (quinolin-2-yl)ethyl, (quinoxalin-2-yl)ethyl; n = 0, 1; X = O, CH2, NMe; R1 = H, Me, R2 = H, Ph, 4-(Me)2NC6H4, etc.] in acid-catalyzed conversions. The Michael accepting groups included vinyl-substituted pyridines, quinoline, and pyrazine. Double conjugate addition reactions was accomplished with 2,6-divinylpyridine and related systems.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., SDS of cas: 105-34-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts