Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Application In Synthesis of 31643-49-9.
Gunsel, Armagan;Taslimi, Parham;Atmaca, Goknur Yasa;Bilgicli, Ahmet T.;Piskin, Hasan;Ceylan, Yusuf;Erdogmus, Ali;Yarasir, M. Nilufer;Gulcin, Ilhami research published 《 Novel potential metabolic enzymes inhibitor, photosensitizer and antibacterial agents based on water-soluble phthalocyanine bearing imidazole derivative》, the research content is summarized as follows. The authors have reported on the synthesis and characterization of water-soluble hydrochloride forms (2a–4a) based on novel peripherally [M = metal-free (2), Zn (II) (3), Ga (III) chloride (4)] phthalocyanines bearing 1-methyl-1H-imidazole-2-thiol substituents. Characterization of all compounds used was supported by spectroscopic techniques such as UV-visible, FTIR 1H NMR, 13C NMR and MALDI-MS, etc. The confirmation of the mol. structure of 4-(1-methyl-1H-imidazole-2-thiol) phthalonitrile (1) by single crystal x-ray diffraction experiment was performed for the 1st time. Besides, the intra/inter-mol. interactions inside the obtained crystal structure were studied. Afterward, the effects of the central metal atoms and solvents on the photophysicochem. properties of the phthalocyanines were analyzed to study their potential to use as a photosensitizer in photodynamic therapy (PDT). The phthalocyanines have therapeutic outcomes for cancer treatment. All compounds have a better ability to inhibit compared to existing tried inhibitors. Among these, the best inhibitors against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes are (4) (Ki 47.71 ± 9.14μM and IC50 68.22) and (3a) (Ki 20.12 ± 3.75μM and IC50 19.24), resp. Also, against α-Glycosidase, (4) showed the highest effect (Ki 9.13 ± 1.05μM and IC50 11.22). Phthalocyanines were performed to gram-neg. and gram-pos. bacteria using min. inhibition concentration (MIC) assay and indicated an antibacterial effect.
31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., Application In Synthesis of 31643-49-9
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts