Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Application of C9H6BrNO.
Godugu, Kumar;Nallagondu, Chinna Gangi Reddy research published 《 Solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines by grindstone chemistry》, the research content is summarized as follows. A solvent and catalyst-free synthesis of imidazo[1,2-a]pyridines was reported in excellent to nearly quant. yields from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25°C to 30°C for 3 to 5 min. The absolute structure of the compound, 2-(3-bromophenyl)-7-methylimidazo[1,2-a]pyridine were determined by X-ray crystallog. This green strategy has several noteworthy advantages such as wide spread substrate scope, short reaction times, water work up and the products did not require any chromatog. purification Moreover, the above method does not require any specialized equipment and is highly economical, environmentally benign and easy to carry out in any laboratory Hence, the developed method meets the concept of “benign by design” and were greener alternative to the reported procedures for the synthesis of imidazo[1,2-a]pyridines.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Application of C9H6BrNO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts