Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Name: 4-(2-Bromoacetyl)benzonitrile.
Gaykar, Rahul N.;George, Malini;Guin, Avishek;Bhattacharjee, Subrata;Biju, Akkattu T. research published 《 An Umpolung Oxa-[2,3] Sigmatropic Rearrangement Employing Arynes for the Synthesis of Functionalized Enol Ethers》, the research content is summarized as follows. An oxa-[2,3] sigmatropic rearrangement involving arynes was reported featuring the umpolung of ketones, where the C=O bond polarity was reversed. The in situ-generated sulfur ylides from β-keto thioethers and arynes underwent efficient rearrangement allowing the facile and robust synthesis of functionalized enol ethers I [R = Me, Ph, 2-thienyl, etc.; R1 = Me, Et, Ph, etc., R2 = Ph, 2,5-di-MeC6H3, 1-naphthyl, etc.; X = O, N] in high yields and excellent functional group compatibility. Preliminary mechanistic studies rule out the possibility of Pummerer-type rearrangement operating in this case.
Name: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts