Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. SDS of cas: 105-34-0.
Ferreira, Joao Marcos Gomes de Oliveira;da Silva, Girlyanderson Araujo;Coelho, Maisa Cavalcanti;Junior, Claudio Gabriel Lima;Vale, Juliana Alves research published 《 Quick synthesis of isatin-derived Knoevenagel adducts using only eco-friendly solvent》, the research content is summarized as follows. A variety of Knoevenagel compounds I (R1 = H, Me, allyl, Bn; R2 = H, Cl, Br, NO2 , R3 = H, Cl; EWG = CN, COOMe, COOEt) from isatin were synthesized using an eco-friendly methodol. It was used only the binary solvent ethanol: water (3:7 volume/volume) without the presence of metal catalyst what enabled the reaction between different isatins with malononitrile in a quick reaction time of 2-5 min and isolated yields 80-96%. When cyanoesters were used as methylene actives, the reactions were longer and the knoenevagel products were obtained in 79-92% isolated yields.
SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts