Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: Methyl 2-cyanoacetate.
Escalante, Carlos H.;Carmona-Hernandez, Fernando A.;Hernandez-Lopez, Alberto;Martinez-Mora, Eder I.;Delgado, Francisco;Tamariz, Joaquin research published 《 Cascade synthesis of indolizines and pyrrolo[1,2-a]pyrazines from 2-formyl-1-propargylpyrroles》, the research content is summarized as follows. A straightforward synthesis of indolizines I [R = H, Ph, 4-MeC6H4, etc.; R1 = H, CHO, Br, etc.; R2 = H, Br; X = C(CO2Me), C(CO2Et), C(CN), C(NO2)] and pyrrolo[1,2-a]pyrazines I [R = H, Ph, 4-MeOC6H4, 3-O2NC6H4; R1 = H, Br, 4-MeOC6H4, 3-O2NC6H4; X = N] was performed through a cascade condensation/cyclization/aromatization reaction of substituted 2-formyl-N-propargylpyrroles with active methylene compounds such as nitromethane, alkyl malonates, Me cyanoacetate and malononitrile. Under basic conditions, the reaction proceeded satisfactorily to provide the corresponding 6,7-disubstituted indolizines. The condensation of the pyrrolic analogs with ammonium acetate gave rise to pyrrolo[1,2-a]pyrazines in high yields. N-Allenyl-2-formylpyrroles behaved as more reactive substrates than 2-formyl-N-propargylpyrroles, furnishing the expected indolizines in higher yields. Hence, an allenyl-containing intermediate was probably generated as the reactive species in the reaction mechanism of some N-propargyl pyrroles prior to the cyclization reaction.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Recommanded Product: Methyl 2-cyanoacetate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts