Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Application of C4H5NO2.
Emami, Leila;Moezi, Leila;Amiri-Zirtol, Leila;Pirsalami, Fatemeh;Divar, Masoumeh;Solhjoo, Aida;Khabnadideh, Soghra research published 《 Anticonvulsant activity, molecular modeling and synthesis of spirooxindole-4H-pyran derivatives using a novel reusable organocatalyst》, the research content is summarized as follows. Fifteen derivatives of spirooxindole-4H-pyran (I R= Et, Bu, 3-methyl-2-butene, sec-Bu, cyclopentyl, benzyl, 3-bromobenzyl, R′= CN, COOCH3, COOC2H5) were subjected to evaluate through i.v. infusion of pentylenetetrazole (PTZ)-induced epilepsy mouse models. Four doses of the compounds (20, 40, 60 and 80 mg/kg) were tested in comparison with diazepam as pos. control. The resulted revealed that compounds[I R=3-methyl-2-butene, R′=CN] and [I R=sec-Bu, R′=COOC2H5] were the most active compounds and indicated significant anticonvulsant activity in the PTZ test. The tested compounds were prepared via a multicomponent reaction using graphene oxide (GO) based on the 1-(2-aminoethyl) piperazine as a novel heterogeneous organocatalyst. The prepared catalyst (GO-A.P.) was characterized using some diverse microscopic and spectroscopic procedures as well. The results showed high catalytic activity of the catalyst in the synthesis of spirooxindole-4H-pyran derivatives The GO-A. P. catalyst was reusable at least for 5 times with no significant decrease in its catalytic action. In silico assessment of physicochem. activity of all compounds also were done which represented appropriate properties. Finally, mol. docking study was performed to achieve their binding affinities as γ-aminobutyric acid-A (GABA-A) receptor agonists as a plausible mechanism of their anticonvulsant action. Binding free energy values of the compounds represented strongly matched with biol. activity.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Application of C4H5NO2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts