Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Formula: C4H5NO2.
Aljaddua, Huda I.;Alhumaimess, Mosaed S.;Hassan, Hassan M. A. research published 《 CaO nanoparticles incorporated metal organic framework (NH2-MIL-101) for Knoevenagel condensation reaction》, the research content is summarized as follows. Porous materials based on NH2-MIL-101(Cr) MOF and their hierarchical acid-base composite with non-precious CaO was successfully prepared using a one-pot scalable hydrothermal approach. The composites were characterized by XRD, FTIR, UV-vis, 1HNMR, TGA, N2 adsorption-desorption isotherms, HRTEM and FESEM. The quant. assessment of the basic sites was performed by benzoic acid titration The results reveal that there is no remarkable structural alterations in the NH2-MIL-101(Cr) after incorporation of CaO. Raising the CaO content boosted the strength of and content of Lewis basic sites from 0.31 to 1.34 mmol g-1 due to the incorporation with CaO (0.04). Knoevenagel condensation reactions were performed as the probe reactions over the CaO/NH2-MIL-101(Cr) catalysts. Both basic and acidic sites potentially boosted the reaction. Pure NH2-MIL-101(Cr) display the catalytic conversion in the reaction (11%) which could be attributed weak basic sites on the NH2-MIL-101(Cr) framework. However, the conversion (%) was potentially increased over NH2-MIL-101(Cr) loaded with various content of CaO. The highest performance of (99%) conversion was achieved for (0.04) CaO/NH2-MIL-101(Cr) catalyst. Exceptional conversion above 90% have been obtained for benzaldehyde derivatives both withdrawing and donating electron moieties. The composites can be recycled in four runs with a very small loss in performance. Furthermore, the composites produced tend to be feasible for various catalytic processes, exploring new avenues to produce of novel inorganic and organic composite materials as heterogeneous catalysts.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Formula: C4H5NO2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts