Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Application In Synthesis of 31643-49-9.
Alici, Esma Hande;Bilgicli, Ahmet T.;Tuzun, Burak;Gunsel, Armagan;Arabaci, Gulnur;Nilufer Yarasir, M. research published 《 Alkyl chain modified metalophthalocyanines with enhanced antioxidant-antimicrobial properties by doping Ag+ and Pd2+ ions》, the research content is summarized as follows. In this study, we report the synthesis and characterization of peripheral alkyl chain-substituted metalophthalocyanines [CuPc (3), ZnPc (4), and CoPc (5)] as optically sensitive substances with antifungal and antibacterial properties. Synthesized compounds were characterized by using common spectroscopic methods such as 1H NMR, 13C NMR, FT-IR, MALDI-TOF, fluorescence, and UV-Vis spectroscopy. Aggregation behaviors of phthalocyanines in the presence of Ag+ and Pd2+ ions were investigated by UV-Vis and fluorescence spectroscopy. The quenching capacity of Ag+ and Pd2+ ions for 4 was calculated from the Stern-Volmer equation and was found to be 9.76 x 104 mol/L and 2.86 x 105 mol/L for Pd2+ and Ag+ ions, resp. The binding stoichiometry (n) and binding constant (Ka) of 4 for Ag+and Pd2+ions were calculated by the changed Benesi-Hildebrand equation. Ka value of 4 for Ag+and Pd2+ions are 2.57 x 109M – 1 and 1.44 x 108M – 1, resp. The binding ratio of 4 for Ag+and Pd2+ions is 1.83 and 1.68, resp. The morphol. features of phthalocyanine derivatives were examined before and after the Ag+or Pd2+ions treatment by SEM (SEM). In addition, the antioxidant efficiencies of newly synthesized metalophthalocyanines and their Ag+ and Pd2+ ion-doped aggregates were evaluated using different methods such as DPPH free radical scavenging, iron ion chelating, and reducing power activities. The chem. and biol. activities of phthalonitrile and its metalophthalocyanines were also evaluated by DFT and mol. docking calculations Finally, the antifungal and antibacterial efficiencies of newly synthesized β-substituted phthalocyanines and their Ag+ and Pd2+ ion-doped forms were investigated using macrobroth dilution and disk diffusion methods.
Application In Synthesis of 31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts