Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Application of C9H6BrNO.
Al-Matarneh, Maria Cristina;Amarandi, Roxana-Maria;Mangalagiu, Ionel I.;Danac, Ramona research published 《 Synthesis and biological screening of new cyano-substituted pyrrole fused (iso)quinoline derivatives》, the research content is summarized as follows. Several new cyano-substituted derivatives with pyrrolo[1,2-a]quinoline I [R = Br, CN, OMe] and pyrrolo[2,1a]isoquinoline II scaffolds were synthesized by the [3+2] cycloaddition of (iso)quinolinium ylides to fumaronitrile. The cycloimmonium ylides reacted in situ as 1,3-dipoles with fumaronitrile to selectively form distinct final compounds, e.g., III depending on the structure of the (iso)quinolinium salt. Eleven compounds were evaluated for their anticancer activity against a panel of 60 human cancercell lines. The most potent compound III showed a broad spectrum of antiproliferative activity against cancer cell lines representing leukemia, melanoma and cancer of lung, colon, central nervoussystem, ovary, kidney, breast and prostate cancer. In vitro assays and mol. docking revealed tubulin interaction properties of compound III.
Application of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts