Month: April 2022

Reference of 5-Chloro-1-methyl-4-nitroimidazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Determination of two related substances in azathioprine tablets by HPLC.

An HPLC method was developed to determine 6-mercaptopurine and 5-chloro-1-methyl-4-nitroimidazole, which were related substances of azathioprine tablets. An ODS C18 column (250 mm × 4.6 mm, 5 μm) was used with the mobile phase of a mixture of sodium heptanesulfonate solution (sodium heptanesulfonate 1.336 g, dissolved in 850 mL water)-methanol (85:15, adjust the solution with 1 mol/L-1 hydrochloric acid to a pH of 3.5) at a flow rate of 1.0 mL/min-1. The detection wavelength was at 254 nm. For 6-mercaptopurine, the calibration curve was linear in the range of 4. 68 ± 10-4 to 0.014 mg/mL-1 with correlation coefficient 0.9997 and the regression equation being Y = 5400X-0.5302. The average recovery (n = 9) was 99.5%, and the detection limit was 1 ng . For 5-chloro-1-methyl-4-nitroimidazole, the calibration curve was also linear in the range of 5. 51 ± 10-4 to 0.0165 mg/mL-1 with correlation coefficient 0.9994 and the regression equation being Y = 6743X-1.396, the average recovery (n = 9) was 99.7%, and the detection limit was 2.5 ng. Sample solution and standard solution are all stable within 8 h. This method is specific, accurate, sensitive, and simple.

《Determination of two related substances in azathioprine tablets by HPLC》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Reference of 5-Chloro-1-methyl-4-nitroimidazole.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions, published in 2013, which mentions a compound: 1445086-17-8, mainly applied to aminobiphenyl palladium precatalyst preparation crystal mol structure; carbon nitrogen cross coupling catalyst aminobiphenyl palladium precatalyst preparation, Name: P(t-Bu)3 Pd G3.

A series of easily prepared, phosphine-ligated palladium precatalysts based on the 2-aminobiphenyl scaffold have been prepared The role of the precatalyst-associated labile halide (or pseudohalide) in the formation and stability of the palladacycle has been examined It was found that replacing the chloride in the previous version of the precatalyst with a mesylate leads to a new class of precatalysts with improved solution stability and that are readily prepared from a wider range of phosphine ligands. The differences between the previous version of precatalyst and that reported here are explored. In addition, the reactivity of the latter is examined in a range of C-C and C-N bond forming reactions.

《Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(P(t-Bu)3 Pd G3)Name: P(t-Bu)3 Pd G3.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called SBA-16 supported amino acid Schiff base complexes of molybdenum as new heterogeneous molybdenum catalysts, published in 2019-06-05, which mentions a compound: 17524-05-9, Name is Bis(acetylacetonato)dioxomolybdenum(VI), Molecular C10H14MoO6, Safety of Bis(acetylacetonato)dioxomolybdenum(VI).

Immobilization of molybdenum complexes of amino acid Schiff bases within the SBA-16 nanocages produced new heterogeneous catalysts for the epoxidation of olefins. First, amino acid Schiff bases were obtained through the reaction of amino acids with salicylaldehyde. Then, complexation of the prepared amino acid Schiff bases with molybdenum (VI) produced the molybdenum complexes of amino acid Schiff bases. Immobilization of the molybdenum complexes into the SBA-16 nanocages followed by silylation with triethoxyoctylsilane gave the heterogenized molybdenum catalysts. The obtained catalysts were characterized with several physicochem. techniques. FT-IR and inductively coupled plasma optical emission (ICP-OES) spectroscopies approved the inclusion of molybdenum complexes within the SBA-16 nanocages. The results of X-ray diffraction (XRD) and nitrogen adsorption-desorption (BET method) analyses illustrated that surface properties of SBA-16 were maintained upon the inclusion of molybdenum complexes. The prepared catalysts exhibited good activities and excellent selectivities (>99%) in the epoxidation of olefins with tert-Bu hydroperoxide (TBHP).

《SBA-16 supported amino acid Schiff base complexes of molybdenum as new heterogeneous molybdenum catalysts》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(acetylacetonato)dioxomolybdenum(VI))Safety of Bis(acetylacetonato)dioxomolybdenum(VI).

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,9-Dimethyl-1,10-phenanthroline hemihydrate( cas:34302-69-7 ) is researched.COA of Formula: C28H26N4O.Ueno, Keihei; Saito, Mikihiko; Iwano, Hidekazu published the article 《Melting point of 2,9-dimethyl-1,10-phenanthroline》 about this compound( cas:34302-69-7 ) in Talanta. Keywords: melting temperature hydration phenanthroline. Let’s learn more about this compound (cas:34302-69-7).

Although the hemihydrate and the dihydrate of 2,9-dimethyl-1,10-phenanthroline (I) showed reliable m.ps. (159-60 and 140-1°, resp.), samples of I at intermediate stages of hydration had m.ps. varying somewhat randomly between 141 and 159°.

《Melting point of 2,9-dimethyl-1,10-phenanthroline》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,9-Dimethyl-1,10-phenanthroline hemihydrate)COA of Formula: C28H26N4O.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Safety of 5-Chloro-1-methyl-4-nitroimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?. Author is Clarke, Eric D.; Wardman, Peter.

Reduction of 5-chloro-1-methyl-2-nitroimidazole (I) using HCO2-/N2O reducing system was characterized, and calculations at 450 nm and pH 2.2-8.3 gave a pKa of 3.3 for the prototropic equilibrium Experiments on the rate of oxidation of I radical by Fe(CN)63- demonstrated that reduction of I by the Me2CHOH/N2O system gave a radical with unit neg. charge at pH 8.2 which was oxidized by Fe(CN)63-. At 410 nm, the I radical produced in the HCO2- system was extremely long-lived at pH >7; the rate of decay increased progressively as pH was lowered and second order rate constants for radical-radical reaction were estimated γ-Radiolysis of N2O-saturated solutions containing I and HCO2- (concentration ratio of HCO2- to I ≃100) at pH 7.4 and 310 nm and Na2S2O4 anaerobic reduction of I indicated that dissociative electron attachment occurs, producing Cl- with high efficiency. The radical produced initially upon reaction of I with simple one-electron reducing agents behaves as a normal nitroimidazole radical-anion on the timescale of pulse radiolysis measurements. If the radical-anion of I dissociates to yield Cl- and a neutral radical, it does so only at times >1 s at pH 7, i.e. possibly accompanying the disproportionation or other reaction of 2 radicals.

《Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Safety of 5-Chloro-1-methyl-4-nitroimidazole.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of C5H5NS. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Optical properties of two bismuth(III) halide hybrids with pyridyl sulfide derivative counter cations. Author is Wang, Zihan; Dan, Qingjuan; Zhao, Ruo-Yu; Xu, Rang-Dong; Liu, Guang-Ning; Li, Cuncheng.

Low dimensional organic-inorganic hybrid Bi(III) halides, especially those containing organic N, S-heterocycles are amazing as solid state photoluminescent materials, but remain less explored. Herein, two bismuth(III) halide compounds, (Etmp)4Bi2X10 (X = Cl for 1, Br for 2, Etmp = 4-(ethylthio)pyridin-1-ium), were obtained by employing pyridyl sulfide derivative as countercations. They are determined as zero-dimensional (0D) ionic structures, featuring binuclear bismuth halide anions charge-compensated by (Etmp)+ countercations. Solid-state UV-visible diffuse reflectance spectra reveal the wide optical band gaps of 3.20 eV for 1 and 2.67 eV for 2. Notably, 1 exhibits a strong green photoluminescence emission with a quantum yield of 20%, and a CIE chromaticity coordinate of (0.27, 0.36) when irradiated by a 394-nm light. Theor. calculations suggest that the charge transition between Cl-3p and p-π* anti-bonding orbital of (Etmp)+ is responsible for the emission.

《Optical properties of two bismuth(III) halide hybrids with pyridyl sulfide derivative counter cations》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Pyridine-4-thiol)Synthetic Route of C5H5NS.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Gold-patterned microarray chips for ultrasensitive surface-enhanced Raman scattering detection of ultratrace samples, published in 2019, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Electric Literature of C5H5NS.

This paper reports the fabrication of gold-patterned microarray chips for fast and ultrasensitive surface enhanced Raman scattering (SERS) detection of trace samples. By micro-nano machining based on electron-beam lithog., magnetron sputtering, and chem. modification, gold-patterned microarray chips with hydrophilic and hydrophobic periodic structures are fabricated, and a polyethylene glycol (PEG) layer is coated on the surface of the gold well, making the chips long-term stable. The hydrophilic surface of each gold well is surrounded by a hydrophobic layer, which makes the ultratrace sample amount for SERS measurement only 0.3μl. In the detection of malachite green (MG), 4-mercaptopyridine (4-MPY), rhodamine 6G (R6G), and melamine, great enhanced SERS signals with the detection limit reaching nM level can be achieved due to the enrichment effect of the periodic structures and the hot-spots generated between the sandwich structure built on the gold wells. Such gold-patterned microarray chip is promising in fast and ultrasensitive SERS detection of various chem. and biol. species with trace amount

《Gold-patterned microarray chips for ultrasensitive surface-enhanced Raman scattering detection of ultratrace samples》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Pyridine-4-thiol)Electric Literature of C5H5NS.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis(acetylacetonato)dioxomolybdenum(VI)(SMILESS: O=[Mo+2]12(O=C([CH-]C(C)=O1)C)(O=C([CH-]C(C)=O2)C)=O,cas:17524-05-9) is researched.Computed Properties of C21H16N2. The article 《Insights into the Structure-Activity Relationship in Aerobic Alcohol Oxidation over a Metal-Organic-Framework-Supported Molybdenum(VI) Catalyst》 in relation to this compound, is published in Journal of the American Chemical Society. Let’s take a look at the latest research on this compound (cas:17524-05-9).

The understanding of structure-activity relations at the at. level has played a profound role in heterogeneous catalysis, providing valuable insights into designing suitable heterogeneous catalysts. However, uncovering the detailed roles of how such active species’ structures affect their catalytic performance remains a challenge owing to the lack of direct structural information on a specific active species. Herein, the authors deposited molybdenum(VI), an active species in oxidation reactions, on the Zr6 node of a mesoporous zirconium-based metal-organic framework (MOF) NU-1200, using solvothermal deposition in MOFs (SIM). Due to the high crystallinity of the NU-1200 support, the precise structure of the resulting molybdenum catalyst, Mo-NU-1200, was characterized through single-crystal x-ray diffraction (SCXRD). Two distinct anchoring modes of the molybdenum species were observed: one mode (Mo1), displaying an octahedral geometry, coordinated to the node through one terminal oxygen atom and the other mode (Mo2) coordinated to two adjacent Zr6 node oxygen atoms in a tetrahedral geometry. To investigate the role of base in the catalytic activity of these Mo centers, the authors assessed the activity of Mo-NU-1200 for the aerobic oxidation of 4-methoxybenzyl alc. as a model reaction. Mo-NU-1200 exhibited remarkably higher catalytic reactivity under base-free conditions, while the presence of base inhibited the catalytic reactivity of this species. SCXRD studies revealed that the molybdenum binding motifs (structures of the supported metal on the Zr6 node in the MOF) changed over the reactions. Following the oxidation without base, both pristine coordination modes (Mo1 and Mo2) evolved into a new coordination mode (Mo3), in which the molybdenum atom coordinated to two adjacent oxygen atoms from the Zr6 node in an octahedral geometry, while in the presence of base, the pristine Mo1 coordination mode evolved entirely into the pristine Mo2. This study demonstrates the direct observation of an active species’ structural evolution from metal installation to subsequent catalytic reaction. As a result, these subtle structural changes in catalyst binding motifs led to distinct differences in catalytic activities, providing a compelling strategy for elucidating structure-activity relations.

《Insights into the Structure-Activity Relationship in Aerobic Alcohol Oxidation over a Metal-Organic-Framework-Supported Molybdenum(VI) Catalyst》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(acetylacetonato)dioxomolybdenum(VI))Electric Literature of C10H14MoO6.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C21H16N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Acidic Ionic Liquid [H-NP]HSO4 Promoted One-Pot Synthesis of Dihydro-1H-Indeno[1,2-b]pyridines and Polysubstituted Imidazoles. Author is Alinezhad, Heshmatollah; Tajbakhsh, Mahmoud; Maleki, Behrooz; Pourshaban Oushibi, Fereshteh.

A green and efficient protocol for the one-pot synthesis of dihydro-1H-indeno[1,2-b]pyridines and polysubstituted imidazoles using a recyclable acidic ionic liquid [H-NP]HSO4 (H-NPBS) was reported. Non-corrosiveness, safe, low waste, generality, simplicity, easy for separation, short reaction times, high yields and environmentally benign were some of the advantages of this methodol. The [H-NP]HSO4 (H-NPBS) was effectively recycled for six consecutive cycles without appreciable loss in its activity.

《Acidic Ionic Liquid [H-NP]HSO4 Promoted One-Pot Synthesis of Dihydro-1H-Indeno[1,2-b]pyridines and Polysubstituted Imidazoles》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4,5-Triphenylimidazole)Computed Properties of C21H16N2.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Pyridine-4-thiol(SMILESS: SC1=CC=NC=C1,cas:4556-23-4) is researched.COA of Formula: C21H16N2. The article 《Long-Range Surface Plasmon Resonance Configuration for Enhancing SERS with an Adjustable Refractive Index Sample Buffer to Maintain the Symmetry Condition》 in relation to this compound, is published in ACS Omega. Let’s take a look at the latest research on this compound (cas:4556-23-4).

We propose a method to maintain the symmetry condition of the refractive index with respect to a dielec. buffer layer for a long-range surface plasmon resonance (LRSPR) configuration. The symmetry condition was maintained by changing the concentration of the ethylene glycol aqueous solution (sample buffer layer) to match the refractive index of the MgF2 film. Maintenance of the symmetry condition is necessary for exciting the LRSPR mode and increasing the elec. field intensity near the film. We used a four-phase Kretschmann resonance setup composed of a K9 prism, MgF2 film, Ag film, and sample buffer layer. The incident angle-dependent surface-enhanced Raman scattering (SERS) spectra were measured in the evanescent field. At the SPR angle, the SERS signal of the sym. configuration was 60 times higher than that of the conventional SPR configuration. Moreover, the elec. field penetration depth of the sym. long-range surface plasmon configuration (>1000 nm) was longer than that of their asym. counterparts. The enhancement factor of the sym. configuration was 8.6 x 107, which corresponded to the lowest detectable concentration for 4-mercaptopyridine, reaching 1.0 x 10-10 M at the resonance angle. Thus, the sym. LRSPR configuration has great potential for label-free sensing and detection of macromols. and biomols.

《Long-Range Surface Plasmon Resonance Configuration for Enhancing SERS with an Adjustable Refractive Index Sample Buffer to Maintain the Symmetry Condition》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Pyridine-4-thiol)Application In Synthesis of Pyridine-4-thiol.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts