Month: April 2022

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloro-1-methyl-4-nitroimidazole(SMILESS: C1=NC(=C(Cl)[N]1C)[N+]([O-])=O,cas:4897-25-0) is researched.COA of Formula: C21H16N2. The article 《A validated UPLC method for the determination of process-related impurities in Azathioprine bulk drug》 in relation to this compound, is published in Analytical Methods. Let’s take a look at the latest research on this compound (cas:4897-25-0).

An UPLC method was developed and subsequently validated for the determination of Azathioprine and its process-related impurities. Separation was achieved with Acquity UPLC BEH C18, 100 × 2.1 mm, 1.7 μm column and trifluoroacetic acid (0.05% in water): acetonitrile as eluent in gradient mode. Flow rate was set at 0.35 mL min-1. UV detection was performed at 220 nm. The method was validated with respect to specificity, accuracy, precision, linearity, robustness, limit of quantification, and limit of detection. The accuracy of the method demonstrated at 3 levels in the range of 50-150% of the specification limit and the recovery of impurities were found to be in the range of 98 to 102%. The detection limits of the process related impurities ranged between 0.16 and 0.24 μg mL-1. The described method is simple, rapid, linear, precise, and robust. The method is useful during process development and quality control of bulk manufacturing

This compound(5-Chloro-1-methyl-4-nitroimidazole)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

COA of Formula: C21H16N2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about A green and simple method for the synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives using acidic ionic liquid as an effective and recyclable catalyst under ultrasound.

An acidic ionic liquid ([{(IMC)-4-OMBH}BIM][HSO4]3) has been utilized as an effective and recyclable catalyst for the synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives I (R = H, 4-Cl, 3,4-dimethoxy, 3-OH, etc.) with high yields under optimal reaction conditions and ultrasound irradiation Important features of the new catalyst are facile synthesis, cheap reagents and successful reuse for many times. What makes the present method an effective contribution in the field of synthesis of 2,4,5-trisubstituted-1H-imidazole derivatives I is the fact that it can be described as environmentally friendly, economical, short reaction time, possible recover of the catalyst, simple workup, safer and mild reaction conditions.

This compound(2,4,5-Triphenylimidazole)COA of Formula: C21H16N2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of C10H14MoO6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Bis(acetylacetonato)dioxomolybdenum(VI), is researched, Molecular C10H14MoO6, CAS is 17524-05-9, about Supramolecular frameworks formed via hydrogen bonding and non-covalent interactions and interaction energy calculations of solvent coordinated cis-dioxomolybdenum(VI) complexes derived from ONO donor aroylhydrazone: Cytotoxicity studies. Author is Kuriakose, Daly; Prathapachandra Kurup, M. R..

A tridentate ONO donor aroylhydrazone, 3,5-diiodosalicylaldehyde-4-methoxybenzoylhydrazone (H2SMB) and four cis-MoO2 complexes [MoO2(SMB)(DMF)] (1), [MoO2(SMB)(DMSO)] (2), [MoO2(SMB)(py)] (3) and [MoO2(SMB)(3-pic)] (4) which vary the solvents/heterocyclic bases in the sixth coordination position were synthesized. The compounds were characterized by different physicochem. methods. The single crystal X-ray diffraction studies unambiguously confirm the mol. structures. In the complexes 1, 2, 3 and 4, the octahedral geometry around the Mo(VI) central atom is satisfied by ONO donor atoms and two oxo oxygens, the sixth coordination site is occupied by oxygen/nitrogen atoms of solvent mols. The supramol. architectures generated by various hydrogen bonding and non-bonding interactions were studied. The interaction energy calculations reveal dominance of dispersion energy component over other components. The aroylhydrazone was screened for antioxidant study using DPPH assay. The in vitro cytotoxicity of Mo(VI) complexes was evaluated against lymphoma ascites cell line as well as against normal cell and compared to hydrazone and cyclophosphamide.

《Supramolecular frameworks formed via hydrogen bonding and non-covalent interactions and interaction energy calculations of solvent coordinated cis-dioxomolybdenum(VI) complexes derived from ONO donor aroylhydrazone: Cytotoxicity studies》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(acetylacetonato)dioxomolybdenum(VI))Electric Literature of C10H14MoO6.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 484-47-9, is researched, SMILESS is C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1, Molecular C21H16N2Journal, Article, ACS Omega called Visible Light-Emitting Diode Light-Driven Cu0.9Fe0.1@RCAC-Catalyzed Highly Selective Aerobic Oxidation of Alcohols and Oxidative Azo-Coupling of Anilines: Tandem One Pot Oxidation-Condensation to Imidazoles and Imines, Author is Patel, Ashok Raj; Patel, Geetika; Banerjee, Subhash, the main research direction is alc aerobic oxidation carbon supported copper iron photocatalytic nanocatalyst; ketone aldehyde preparation green chem; aniline oxidative azo coupling carbon supported copper iron nanocatalyst; diazo compound preparation green chem; tandem one pot oxidation condensation carbon supported copper iron; imidazoles imine preparation green chem.Safety of 2,4,5-Triphenylimidazole.

Here, we have demonstrated visible light-emitting diode light-driven selective and efficient aerobic oxidation of primary/secondary alcs. to aldehydes/ketones and oxidative azo-coupling of anilines using biomass rice husk-derived chem. activated carbon sheet-supported copper-iron bimetallic hybrid nanomaterials (CuxFe1-x@RCAC) under oxidant and additive-free conditions. The catalytic activity of the CuxFe1-x@RCAC materials has been investigated for the oxidation of alcs. and anilines, and Cu0.9Fe0.1@RCAC was established as the best catalyst. Moreover, a tandem one-pot protocol has been developed for the sequential oxidation of alcs. followed by condensation to functionalized imidazole and imine derivatives in high isolated yields. The hybrid materials were highly robust and stable under the reaction conditions and were recovered simply by filtration and recycled up to 12th run without considerable loss in catalytic activity.

《Visible Light-Emitting Diode Light-Driven Cu0.9Fe0.1@RCAC-Catalyzed Highly Selective Aerobic Oxidation of Alcohols and Oxidative Azo-Coupling of Anilines: Tandem One Pot Oxidation-Condensation to Imidazoles and Imines》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4,5-Triphenylimidazole)Safety of 2,4,5-Triphenylimidazole.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1445086-17-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: P(t-Bu)3 Pd G3, is researched, Molecular C25H40NO3PPdS, CAS is 1445086-17-8, about Optimum catalyst selection over continuous and discrete process variables with a single droplet microfluidic reaction platform. Author is Baumgartner, Lorenz M.; Coley, Connor W.; Reizman, Brandon J.; Gao, Kevin W.; Jensen, Klavs F..

A mixed-integer nonlinear program (MINLP) algorithm to optimize catalyst turnover number (TON) and product yield by simultaneously modulating discrete variables-catalyst types-and continuous variables-temperature, residence time, and catalyst loading-was implemented and validated. Several simulated case studies, with and without random measurement error, demonstrate the algorithm’s robustness in finding optimal conditions in the presence of side reactions and other complicating nonlinearities. This algorithm was applied to the real-time optimization of a Suzuki-Miyaura cross-coupling reaction in an automated microfluidic reaction platform comprising a liquid handler, an oscillatory flow reactor, and an online LC/MS. The algorithm, based on a combination of branch and bound and adaptive response surface methods, identified exptl. conditions that maximize TON subject to a yield constraint from a pool of eight catalyst candidates in just 60 experiments, considerably fewer than a previous version of the algorithm.

《Optimum catalyst selection over continuous and discrete process variables with a single droplet microfluidic reaction platform》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(P(t-Bu)3 Pd G3)Related Products of 1445086-17-8.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Catalytic activity of Co(II) Salen@KCC-1 on the synthesis of 2,4,5-triphenyl-1H-imidazoles and benzimidazoles.Application In Synthesis of 2,4,5-Triphenylimidazole.

The synthesis, reactions and biol. properties of imidazoles and benzimidazole make up the bulk of the ring chem. The reaction between different types of aromatic aldehydes and ammonium acetate with diphenylethanedione, in ethanol solvent, using the Co(II) Salen complex@KCC-1 catalyst which was produced from Co(II) complex which is supported onto the KCC-1 was studied. The products were synthesized in good to excellent yields. The products were identified with IR and NMR spectroscopy. Also, the catalyst was identified by FTIR, TGA, TEM, and XRD. Finally, the catalyst was reused several times without lack of catalytic activity.

《Catalytic activity of Co(II) Salen@KCC-1 on the synthesis of 2,4,5-triphenyl-1H-imidazoles and benzimidazoles》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4,5-Triphenylimidazole)Application In Synthesis of 2,4,5-Triphenylimidazole.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 5-Chloro-1-methyl-4-nitroimidazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Nitroimidazoles. Part V. Chloronitroimidazoles from dinitroimidazoles. A reinvestigation. Author is Suwinski, Jerzy; Salwinska, Ewa; Watras, Jan; Widel, Maria.

5(4)-Chloro- and 2-chloro-4(5)-nitroimidazole or their N-Me derivatives were prepared by ≥2 independent routes. Contrary to some former reports, only 2-chloro-4-(or 5)-nitroimidazoles were obtained from 2,4(or 5)-dinitroimidazoles. In 4,5-dinitroimidazoles only a nitro group in the 5 position was replaced by a chlorine atom.

《Nitroimidazoles. Part V. Chloronitroimidazoles from dinitroimidazoles. A reinvestigation》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Name: 5-Chloro-1-methyl-4-nitroimidazole.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jameel, Dunya A.; Hussein, Mouayed A.; Bader, Mohammed J. published an article about the compound: Bis(acetylacetonato)dioxomolybdenum(VI)( cas:17524-05-9,SMILESS:O=[Mo+2]12(O=C([CH-]C(C)=O1)C)(O=C([CH-]C(C)=O2)C)=O ).Reference of Bis(acetylacetonato)dioxomolybdenum(VI). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17524-05-9) through the article.

In mole ratio 1:2, six molybdenum (VI) complexes were synthesized by the reaction of MoO2(acac)2 with semicarbazone ligands derived from 4-methylbenzaldehyde (1A and 2A), and 4-methoxybenzaldehyde (1B and 2B). The synthesized ligands and complexes were structurally characterized by CHNS elemental anal. and FTIR, 1HNMR and 13CNMR spectroscopic techniques. The DNA binding activity with all the compounds was investigated using the spectral titration method and the viscosity measurement. The results revealed the external groove binding mode of the ligands 2A, 1B and 2B, and all the complexes with DNA while, the ligand 1A showed an intercalation binding with DNA. The calculated binding constants (Kb) were extracted and the values exhibited a noticed binding strength with DNA.

《Spectroscopic elucidation and dna binding evaluation of molybdenum (VI) with 4-methyl (methoxy) benzaldehyde semicarbazone》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(acetylacetonato)dioxomolybdenum(VI))Reference of Bis(acetylacetonato)dioxomolybdenum(VI).

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of C10H14MoO6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Bis(acetylacetonato)dioxomolybdenum(VI), is researched, Molecular C10H14MoO6, CAS is 17524-05-9, about Synthesis, spectral, FMOs and NLO properties based on DFT calculations of dioxidomolybdenum(VI) complex. Author is Parte, M. K.; Vishwakarma, P. K.; Jaget, P. S.; Maurya, R. C..

Mononuclear dioxidomolybdenum(VI) complex with N-(dehydroacetic acid)-salicylic acid hydrazide having the formula [MoVIO2(dha-sah)(CH3OH)] is reported. The complex was synthesized by reaction of [MoVIO2(acac)2] with the said ligand in 1:1 metal-ligand ratio in methanol. The complex was characterized by elemental anal., 1H and 13C NMR, FTIR, electronic absorption spectroscopic and powd. x-ray diffractometry studies. Assignments of mol. geometrical parameters, mol. electrostatic potentials, nonlinear optical properties and frontier MOs of the titled complex were performed with the Gaussian 09 software package using d. functional theory methods with B3LYP hybrid exchange-correlation functional and the standard LANL2DZ basis set. The exptl. spectral anal. was found in good agreement with the theor. results. The overall study revealed that the complex under study possesses a distorted octahedral geometry.

《Synthesis, spectral, FMOs and NLO properties based on DFT calculations of dioxidomolybdenum(VI) complex》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Bis(acetylacetonato)dioxomolybdenum(VI))Synthetic Route of C10H14MoO6.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

COA of Formula: C21H16N2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions.

A TMSOTf-catalyzed synthesis of trisubstituted imidazoles through the reaction of 1,2-diketones and aldehydes using hexamethyldisilazane as a nitrogen source under microwave heating and solvent-free conditions was developed. The chem. structures of representative trisubstituted imidazoles were confirmed using X-ray single-crystal diffraction anal. This synthetic method had several advantages including the involvement of mild Lewis acid, being metal- and additive-free, wide substrate scope with good to excellent yields and short reaction time. Furthermore, the application of the methodol. was demonstrated in the synthesis of biol. active imidazole-based drugs.

《TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4,5-Triphenylimidazole)COA of Formula: C21H16N2.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts