The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole.Carvalho, Alcione S.; Ferreira, Edmir F.; Soares, Renata O. A.; Souza, Adriano S.; Pinto, Angelo C.; Bozza, Marcelo; Boechat, Nubia published the article 《Synthesis of azoles distinguishing a trifluoromethyl derivative with potent dual anti-Trypanosoma cruzi activity and cell growth inhibitions》 about this compound( cas:4897-25-0 ) in Fluorinated Bioactive Compounds in the Agricultural & Medical Fields, Proceedings of the Conference, Brussels, Sept. 13-15, 1999. Keywords: conference trifluoromethyl azole preparation trypanosomicide; nitroimidazolyl trifluoromethyl triazolamine preparation trypanosomicide; proliferation inhibitor methylnitropyrazolylimidazole methylnitroimidazolyl triazolamine preparation; nitro pyrazolyl imidazole preparation trypanosomicide. Let’s learn more about this compound (cas:4897-25-0).
A conference report. The synthesis of N-(1-methyl-4-nitro-1H-imidazol-5-yl)-5-(trifluoromethyl)-1H-1,2,4-triazol-3-amine and 1-methyl-4-nitro-5-(1H-pyrazol-1-yl)-1H-imidazole and their trypanosomicidal activity were reported.
This compound(5-Chloro-1-methyl-4-nitroimidazole)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts