Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4897-25-0, is researched, Molecular C4H4ClN3O2, about The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds. I. Synthesis of azathioprine, the main research direction is azathioprine optimized preparation; chloroimidazole reaction mercaptopurine; imidazole chloro reaction mercaptopurine; purine mercapto reaction chloroimidazole.Category: nitriles-buliding-blocks.
The reaction conditions for the synthesis of azathioprine (I) were optimized with the help of UV spectroscopy. Thus, 0.029 mol imidazole II in 25 cm3 DMF was stirred into 0.029 mol 6-mercaptopurine hydrate in 15 cm3 DMF, 20 cm2 THF, and 40 cm3 25% aqueous NH4OH and the mixture heated to 70-90° 1.5 h to give 95% crude azathioprine, purified to give 80% product.
This compound(5-Chloro-1-methyl-4-nitroimidazole)Category: nitriles-buliding-blocks was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts