The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid( cas:117918-23-7 ) is researched.Name: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid.Zhang, Meihui; Nguyen, Jeffrey-Tri; Kumada, Henri-Obadja; Kimura, Tooru; Cheng, Maosheng; Hayashi, Yoshio; Kiso, Yoshiaki published the article 《Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme》 about this compound( cas:117918-23-7 ) in Bioorganic & Medicinal Chemistry. Keywords: HTLVI protease inhibitor tetrapeptide preparation structure activity relationship. Let’s learn more about this compound (cas:117918-23-7).
Adult T-cell leukemia and tropical spastic paraparesis/HTLV-I-associated myelopathy are only some of the more common end results of an infection with a human T-cell leukemia virus type 1 (HTLV-I). Expanding from their previous reports, the authors have synthesized all different permutations of tetrapeptidic HTLV-I protease inhibitors using at least eight P3-cap and five P’1-cap moieties. The inhibitors exhibited over 97% inhibition against HIV-1 protease and a wide range of inhibitory activity against HTLV-I protease.
Different reactions of this compound((R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid)Name: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid require different conditions, so the reaction conditions are very important.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts