Safety of 5-Chloro-1-methyl-4-nitroimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?. Author is Clarke, Eric D.; Wardman, Peter.
Reduction of 5-chloro-1-methyl-2-nitroimidazole (I) using HCO2-/N2O reducing system was characterized, and calculations at 450 nm and pH 2.2-8.3 gave a pKa of 3.3 for the prototropic equilibrium Experiments on the rate of oxidation of I radical by Fe(CN)63- demonstrated that reduction of I by the Me2CHOH/N2O system gave a radical with unit neg. charge at pH 8.2 which was oxidized by Fe(CN)63-. At 410 nm, the I radical produced in the HCO2- system was extremely long-lived at pH >7; the rate of decay increased progressively as pH was lowered and second order rate constants for radical-radical reaction were estimated γ-Radiolysis of N2O-saturated solutions containing I and HCO2- (concentration ratio of HCO2- to I ≃100) at pH 7.4 and 310 nm and Na2S2O4 anaerobic reduction of I indicated that dissociative electron attachment occurs, producing Cl- with high efficiency. The radical produced initially upon reaction of I with simple one-electron reducing agents behaves as a normal nitroimidazole radical-anion on the timescale of pulse radiolysis measurements. If the radical-anion of I dissociates to yield Cl- and a neutral radical, it does so only at times >1 s at pH 7, i.e. possibly accompanying the disproportionation or other reaction of 2 radicals.
《Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Chloro-1-methyl-4-nitroimidazole)Safety of 5-Chloro-1-methyl-4-nitroimidazole.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts