In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Structure-activity studies of FIV and HIV protease inhibitors containing allophenylnorstatine, published in 2001-05-31, which mentions a compound: 117918-23-7, mainly applied to FIV HIV protease inhibitor allophenylnorstatine derivative preparation; structure activity FIV HIV protease inhibitor allophenylnorstatine derivative, Electric Literature of C11H19NO4S.
The interaction of P1 and P3 side chains with the combining S1 and S3 hydrophobic subsites of HIV and FIV proteases has been explored using asym. competitive inhibitors. The inhibitors evaluated contained (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid (allophenylnorstatine) as the hydroxymethylcarbonyl isostere, (R)-5,5-dimethyl-1, 3-thiazolidine-4-carbonyl as P1′, Val as P2 and P2′ residues, and a variety of amino acids at the P3 and P3′ positions. All inhibitors showed competitive inhibition of both enzymes with higher potency against the HIV protease in vitro. Within this series, VLE776 is the most effective inhibitor against FIV protease, and it contains Phe at P3, but no P3′ residue. VLE776 also exhibited potent antiviral activities against the drug-resistant HIV mutants (G48V and V82F) and the TL3-resistant HIV mutants. Explanation of the inhibition activities was described. In addition, a new strategy was described for development of bifunctional inhibitors, which combine the protease inhibitor and another enzyme inhibitor in one mol.
After consulting a lot of data, we found that this compound(117918-23-7)Electric Literature of C11H19NO4S can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts