Related Products of 117918-23-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors. Author is Nguyen, Jeffrey-Tri; Kato, Keiko; Kumada, Henri-Obadja; Hidaka, Koushi; Kimura, Tooru; Kiso, Yoshiaki.
The human T cell lymphotropic/leukemia virus type 1 (HTLV-I) causes adult T cell lymphoma/leukemia. The virus is also responsible for chronic progressive myelopathy and several inflammatory diseases. To stop the manufacturing of new viral components, in our previous reports, we derived small tetrapeptidic HTLV-I protease inhibitors with an important amide-capping moiety at the P3 residue. In the current study, we removed the P3-cap moiety and, with great difficulty, optimized the P3 residue for HTLV-I protease inhibition potency. We discovered a very potent and small tetrapeptidic HTLV-I protease inhibitor (KNI-10774a, IC50 = 13 nM).
After consulting a lot of data, we found that this compound(117918-23-7)Related Products of 117918-23-7 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts