Hidaka, Koushi; Kimura, Tooru; Tsuchiya, Yumi; Kamiya, Mami; Ruben, Adam J.; Freire, Ernesto; Hayashi, Yoshio; Kiso, Yoshiaki published the article 《Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II》. Keywords: allophenylnorstatine tripeptidomimetic preparation inhibitor malarial aspartic protease plasmepsin; plasmepsin inhibitor allophenylnorstatine tripeptidomimetic preparation structure activity relationship; antimalarial agent allophenylnorstatine tripeptidomimetic preparation.They researched the compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid( cas:117918-23-7 ).Application In Synthesis of (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:117918-23-7) here.
Based on a highly potent allophenylnorstatine-containing inhibitor, KNI-10006, against the plasmepsins of Plasmodium falciparum, the authors synthesized a series of tripeptide-type compounds with various N-terminal moieties and evaluated their inhibitory activities against plasmepsin II (Plm II). Certain phenylacetyl derivatives exhibited extremely high affinity with Ki < 0.1 nM suggesting successful hydrophobic interactions. Compounds in my other articles are similar to this one((R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid)Application In Synthesis of (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts