The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ) is researched.Category: nitriles-buliding-blocks.Gabla, Jenifer J.; Lathiya, Dharmesh R.; Revawala, Akash A.; Maheria, Kalpana C. published the article 《Propyl-SO3H functionalized SBA-15: Microwave-mediated green synthesis of biologically active multi-substituted imidazole scaffolds》 about this compound( cas:484-47-9 ) in Research on Chemical Intermediates. Keywords: SBA15 propysulfate catalyst preparation multicomponent heterocyclization catalyst; imidazole multicomponent solventless green synthesis; microwave irradiation multicomponent solventless heterocyclization mediator. Let’s learn more about this compound (cas:484-47-9).
Propylsulfonic acid functionalized Santa Barbara Amorphous-15 (SBA-15-Pr-SO3H) catalyst has been synthesized using a surface modification of mesoporous SBA-15 via the one-pot co-condensation method. The synthesized SBA-15-Pr-SO3H has been characterized by peculiar characterization techniques such as small- and wide-angle XRD, SEM-EDX, TEM, TG-DTA, acidity, FT-IR, Py-FT-IR and BET surface area anal. The catalytic activity of synthesized catalyst has been studied towards solvent-free MW irradiation for the green and rapid synthesis of multi-substituted imidazoles, [2,4,5-triphenyl-1(H)-imidazole (tri-imidazole) and 1-benzyl-2,4,5-triphenyl-1H-imidazole (tetra-imidazole)]. The SBA-15-Pr-SO3H catalyst was found to be an efficient and recyclable solid acid catalyst and this solvent-free MW protocol afforded products in good to excellent yields of both, tri and tetra imidazoles (> 95%) within shorter reaction time (3 min) at 600 W as compared to the SBA-15 and other existing protocols. The applicability of this protocol was further explored by conducting the experiments in the presence of varied solvents and substituted aldehydes to generate a library of both, tri- and tetra-imidazole scaffolds. The catalyst was found to be reusable up to several runs without loss of its catalytic activity. This report allows the rapid and scalable access to a variety of multi-substituted imidazoles using SBA-15-Pr-SO3H, as heterogeneous catalyst.
Although many compounds look similar to this compound(484-47-9)Category: nitriles-buliding-blocks, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts