The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Pyridine-4-thiol(SMILESS: SC1=CC=NC=C1,cas:4556-23-4) is researched.Safety of Pyridine-4-thiol. The article 《Monitoring the Changes of pH in Lysosomes during Autophagy and Apoptosis by Plasmon Enhanced Raman Imaging》 in relation to this compound, is published in Analytical Chemistry (Washington, DC, United States). Let’s take a look at the latest research on this compound (cas:4556-23-4).
Lysosomes are acidic organelles that not only participate in intracellular degradation but also relate to various cellular functions. Abnormal pH in lysosomes would lead to lysosomal dysfunction, which may further result in many diseases. In this work, the authors statistically analyze the pH change in the lysosomes of HeLa cells model by using surface enhanced Raman scattering (SERS) imaging technique. The authors prepared a plasmon Raman pH probe and localized the pH probe to lysosomes via an incubation-depletion method. The pH profiles within lysosomes during the process of cellular autophagy and apoptosis were monitored in situ by SERS imaging. The pH in lysosomes decreased slightly during the process of autophagy, while the pH in lysosomes increased during apoptosis. The phenomenon, in general, is consistent with the current biol. knowledge. However, the authors did not observe significant variation of pH between different individual cells. This information might provide an in depth understanding about the relationship of lysosomal pH with fundamental cellular functions and mechanism of diseases.
Although many compounds look similar to this compound(4556-23-4)Application of 4556-23-4, numerous studies have shown that this compound(SMILES:SC1=CC=NC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts