Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4897-25-0, is researched, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2Journal, Huaxue Yanjiu Yu Yingyong called A new synthetic technique of 5-chloro-1-methyl-4-nitroimidazole, Author is Liu, Cong; Yan, Xiaofei; Ren, Yingge; Shen, Ning; Liu, Qianfeng, the main research direction is chloro methyl nitroimidazole preparation Azathioprine intermediate.Safety of 5-Chloro-1-methyl-4-nitroimidazole.
A method for the preparation of 5-chloro-1-methyl-4-nitroimidazole was developed with di-Et oxalate, aqueous methylamine formate, phosphorus pentachloride, mixed acid etc as starting materials. The synthesis of the target compound was achieved (64% yield) by a sequence involving an aminolysis reaction, condensation and nitration reaction. The process provided an energy-saving high yield synthetic method (green chem.) and the product thus obtained was confirmed by MS, NMR, FT-IR. The title compound is an intermediate for 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine [Azathioprine, Imuran, immunosuppressant].
After consulting a lot of data, we found that this compound(4897-25-0)Safety of 5-Chloro-1-methyl-4-nitroimidazole can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts