Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 484-47-9, is researched, Molecular C21H16N2, about Room temperature ionic liquid promoted improved and rapid synthesis of highly functionalized imidazole and evaluation of their inhibitory activity against human cancer cells, the main research direction is trisubstituted imidazole green preparation antitumor human docking SAR; tetrasubstituted imidazole green preparation antitumor human docking SAR.HPLC of Formula: 484-47-9.
In this study, the use of a 1,8-diazabicyclo [5.4.0]-undec-7-en-8-ium imidazolate ionic liquid as a catalyst as well as a green solvent for the expeditious multicomponent transformation of trisubstituted imidazoles I [Ar = Ph, 4-MeOC6H4; R = n-Bu, Ph, 2-furyl, etc.] and tetrasubstituted imidazoles II [R1 = Ph, 4-ClC6H4, 2-thienyl, etc.; R2 = n-Bu, Ph, 4-FC6H4, etc.; R3 = Ph, 4-MeOC6H4] via pseudo-four- and four-component reactions with short reaction time, excellent yield and purity of products was reported. The ionic liquid was cheap, biodegradable and could be recovered and reused for more than five consecutive cycles. The advantage of this protocol for gram-scale synthesis added to its practical applicability. Selected synthesized tetra- and trisubstituted imidazole scaffolds were screened for their in vitro antiproliferative properties against the human cancer cell lines EC-109, MCF-7, HGC-27, and PC-3. Compounds I [R = 2,6-di-ClC6H3, Ar = Ph], II [R1 = 4-ClC6H4, R2 = 4-MeC6H4, R3 = Ph] and II [R1 = 4-ClC6H4, R2 = Ph, R3 = 4-MeOC6H4] showed potent cytotoxic activity against the human breast cancer cell line PC-3, MCF-7 and HGC-27, resp.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts