The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Bis(acetylacetonato)dioxomolybdenum(VI)( cas:17524-05-9 ) is researched.Name: Bis(acetylacetonato)dioxomolybdenum(VI).Eglence-Bakir, Songul; Sahin, Musa; Zahoor, Muhammad; Dilmen-Portakal, Eylem; Ulkuseven, Bahri published the article 《Synthesis and biological potentials of dioxomolybdenum(VI) complexes with ONS and ONN chelating thiosemicarbazones: DNA-binding, antioxidant and enzyme inhibition studies》 about this compound( cas:17524-05-9 ) in Polyhedron. Keywords: molybdenum oxo salicylidene thiosemicarbazone complex preparation crystal structure; antibacterial activity molybdenum oxo salicylidene thiosemicarbazone complex; antioxidant activity molybdenum oxo salicylidene thiosemicarbazone complex; enzyme inhibitor molybdenum oxo salicylidene thiosemicarbazone complex; anticholinesterase antidiabetic activity molybdenum oxo salicylidene thiosemicarbazone complex; DNA interaction molybdenum oxo salicylidene thiosemicarbazone complex. Let’s learn more about this compound (cas:17524-05-9).
In this study dioxomolybdenum (vi) complexes of 5-methoxysalicylidene N- or S-alkyl substituted thiosemicarbazones {where alkyl is N-Me (L1), N-octyl (L2), S-Me (L3) or S-octyl (L4)} were synthesized, characterized by different spectroscopic techniques (UV, IR, 1H NMR). The structure of the complex with S-methyl-substituted thiosemicarbazone (complex 3) was also determined by x-ray diffraction method. The compounds were evaluated for their antibacterial, antioxidant, anticholinesterase, antidiabetic, and DNA interaction potentials. K. pneumonia was more potently inhibited by ligand L3 (29 ± 0.025 mm zone of inhibition) while E. coli and S. typhi by complex 2 with zone of inhibition of ∼28 ± 0.082 and 26 ± 0.245 mm, resp. Complex 2 more potently scavenged DPPH free radical with IC50 of 231μg/mL while ABTS by ligand L1 (IC50 = 350μg/mL). Complex 4 with S-octyl has high percent inhibition of acetylcholinesterase with IC50 of 104μg/mL. Complex 4 strongly inhibited α-amylase with an IC50 value of 153μg/mL while ligand L4 with IC50 value of 285μg/mL was more potent inhibitor of α-glucosidase. DNA interaction studies revealed the noncovalent interaction of these compounds with DNA. Highest binding constant among these compounds was recorded for ligand L2 with blue shifts and hyperchromism while lowest for L3.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts