Formula: C4H4ClN3O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Metabolic fate of the methylnitroimidazole moiety of azathioprine in the rat. Author is De Miranda, Paulo; Beacham, Lowrie M. III; Creagh, Teresa H.; Elion, Gertrude B..
The major unbound radioactive metabolite of 14C-labeled azathioprine (I) [446-86-6], labeled on the methylnitroamidazole ring, in rat liver homogenates, was 1-methyl-4-nitro-5-(S-glutathionyl)imidazole [36892-55-4] while .sim.10% of the radioactivity was bound to protein. The major urinary metabolite was 1-methyl-4-nitro-5-(N-acetyl-S-cysteinyl)imidazole [51052-82-5], which was a biotransformation product of the glutathionyl imidazole. The metabolite was also isolated from rat liver perfusates by incubation of I with blood and in vivo in the blood, but not in the urine, of rats given I. The various modes of splitting of I and of the formation of 1-methyl-4-nitro-5-thiomidazole [6339-54-4] are discussed and a pathway for the metabolic alteration of I into its principal methylnitroimidazole metabolites in the rat was proposed.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts