Product Details of 4897-25-0. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Highly selective solid phase extraction and preconcentration of Azathioprine with nano-sized imprinted polymer based on multivariate optimization and its trace determination in biological and pharmaceutical samples. Author is Davarani, Saied Saeed Hosseiny; Zad, Zeinab Rezayati; Taheri, Ali Reza; Rahmatian, Nasrin.
In this research, for first time selective separation and determination of Azathioprine is demonstrated using molecularly imprinted polymer as the solid-phase extraction adsorbent, measured by spectrophotometry at λmax 286 nm. The selective molecularly imprinted polymer was produced using Azathioprine and methacrylic acid as a template mol. and monomer, resp. A molecularly imprinted solid-phase extraction procedure was performed in column for the analyte from pharmaceutical and serum samples. The synthesized polymers were characterized by IR spectroscopy (IR), field emission SEM (FESEM). In order to investigate the effect of independent variables on the extraction efficiency, the response surface methodol. (RSM) based on Box-Behnken design (BBD) was employed. The anal. parameters such as precision, accuracy and linear working range were also determined in optimal exptl. conditions and the proposed method was applied to anal. of Azathioprine. The linear dynamic range and limits of detection were 2.5-0.01 and 0.008 mg L- 1 resp. The recoveries for analyte were higher than 95% and relative standard deviation values were found to be in the range of 0.83-4.15%. This method was successfully applied for the determination of Azathioprine in biol. and pharmaceutical samples.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts