Related Products of 4897-25-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about The kinetics of the reaction of ‘anomalous’ 4-nitroimidazole radiosensitizers with thiols. Author is Wardman, P..
Kinetic data for the nonenzymic conjugation of GSH [70-18-8] and dithiothreitol [3483-12-3] with the radiosensitizers, 5-chloro-1-methyl-4-nitroimidazole [4897-25-0] and Ro 31-0750 [13755-79-8], provided upper limits for the half-lives of these compounds when administered in vivo, and suggest that thiol depletion by such compounds in vitro is probably accelerated by glutathione S-transferases. The substantial enhancement of radiosensitization caused by nonprotein thiol depletion may be restricted to dilute cell suspensions in vitro since depletion of a significant proportion of nonprotein thiol in vivo seems unlikely at realistic dose regimes in man.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts