Safety of 2,9-Dimethyl-1,10-phenanthroline hemihydrate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,9-Dimethyl-1,10-phenanthroline hemihydrate, is researched, Molecular C28H26N4O, CAS is 34302-69-7, about Copper-Catalyzed Formal [3 + 3] Annulations of Arylketoximes and o-Fluorobenzaldehydes: An Entry to Quinoline Compounds. Author is Xu, Zhenhua; Chen, Hongbiao; Deng, Guo-Jun; Huang, Huawen.
A copper-based catalytic system had been developed to enable efficient cyclization of ketoxime acetates with o-fluorobenzaldehydes to obtain benzo[c]acridines I [R = H, 9-Me, 2-Br, etc.]. This protocol offered an efficient method for the synthesis of substituted quinoline derivatives with a broad range of compatible functionalities. The present system also provided a rapid access to synthetically and pharmaceutically useful quinoline-fused polycycles such as benzo[c]acridines.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts