Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Studies on five-membered heterocycles. I. Synthesis of nitrochloroimidazoles.Synthetic Route of C4H4ClN3O2.
Chloronitroimidazoles I (R = H, R1 = H, Me; R = Me, R1 = H) were obtained in 70-5% yields by heating the corresponding dinitroimidazole with POCl3 in DMF 2-6 h at 80-5°. Heating II (R = H, X = NO2) with POCl3 2 h gave 68% II (R = H, X = Cl); II (R = Me; X = NO2) gave 60% 4-chloro-1-methyl-2-nitroimidazole.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts