The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ) is researched.SDS of cas: 484-47-9.Higuera, Natalia Lopez; Pena-Solorzano, Diana; Ochoa-Puentes, Cristian published the article 《Urea-Zinc Chloride Eutectic Mixture-Mediated One-Pot Synthesis of Imidazoles: Efficient and Ecofriendly Access to Trifenagrel》 about this compound( cas:484-47-9 ) in Synlett. Keywords: eutectic solvent catalyzed cyclocondensation dicarbonyl ammonium acetate aromatic aldehyde; urea zinc chloride eutectic solvent catalyzed imidazole synthesis; trifenagrel synthesis. Let’s learn more about this compound (cas:484-47-9).
The low-melting mixture urea-ZnCl2 was evaluated as a novel reaction medium for the synthesis of imidazoles. The reaction between a dicarbonyl compound, ammonium acetate, and an aromatic aldehyde is efficiently catalyzed by the eutectic solvent, yielding a wide variety of triaryl-1H-imidazoles or 2-aryl-1H-phenanthro[9,10-d]imidazoles in good to excellent yields [e.g., benzil + benzaldehyde + ammonium acetate → lophine (99%)]. In addition, the eutectic solvent was reused in five cycles without loss of its catalytic activity. This protocol was further explored for the synthesis of the drug trifenagrel, giving an excellent yield.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts