SDS of cas: 484-47-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about An alternative process for one-pot multicomponent synthesis of substituted 2,4,5-triphenylimidazoles using activated Fuller’s earth as catalyst and molecular modeling data. Author is Tanna, Jay A.; Ali, Parvez S.; Gandhare, Nilesh V.; Agrawal, Lucky R.; Upare, Saurabh S.; Mousa, Khalid M. Al.
The synthesis of 2,4,5-trisubstituted imidazoles by one-pot multicomponent reaction of benzil, aromatic benzaldehydes and ammonium acetate in presence of activated fuller’s earth as a catalyst is reported. The activation of fuller’s earth is carried out by an organic acid, which sufficiently increased its adsorption properties. The advantages of this process are high yields, green system and efficient recovery of the catalyst, which can be reused 2-3 times without much significant effect on yield. Mol. modeling studies viz., Lipinski rule of five, drug likeness, drug scores, toxicity profiles and other physico-chem. properties of drugs were performed using Molinspiration and Osiris software and compared with the data of standard drug mol.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts