So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gaudet, Alexandre; Portier, Lucie; Mathieu, Daniel; Hureau, Maxence; Tsicopoulos, Anne; Lassalle, Philippe; Caires, Nathalie De Freitas researched the compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ).COA of Formula: C4H4ClN3O2.They published the article 《Cleaved endocan acts as a biologic competitor of endocan in the control of ICAM-1-dependent leukocyte diapedesis》 about this compound( cas:4897-25-0 ) in Journal of Leukocyte Biology. Keywords: sepsis diapedesis respiratory distress syndrome leukocyte ICAM1 p14 endocan; acute lung injury; cleaved endocan; endocan; inflammation; leukocyte diapedesis; p14. We’ll tell you more about this compound (cas:4897-25-0).
Dysregulated leukocyte diapedesis is a major contributor to acute severe inflammatory states like sepsis and acute respiratory distress syndrome, which are common conditions in critically ill subjects. Endocan is a circulating proteoglycan that binds to the leukocyte integrin LFA-1 and blocks its interaction with its endothelial ligand ICAM-1, subsequently leading to the inhibition of leukocyte recruitment. Recent data have highlighted the hypothetic role of p14, endocan′s major catabolite found in the bloodstream of septic patients, as a potential antagonist of endocan, thus participating in the regulation of acute inflammation. We hereby characterize the role of p14 as a biol. competitor of endocan, through assessment of its mol. interactions with LFA-1, endocan, and ICAM-1, as well as its effects on human leukocyte trafficking. Using immunodetection assay, we report that p14 can bind to LFA-1, thus inhibiting the interaction between LFA-1 and endocan, which in turn leads to the restoration of the ICAM-1/LFA-1 interaction. In primary human T cells trafficking assays, we underline the absence of effect of p14 on ICAM-1-dependent adhesion and migration, as well as on transendothelial migration. However, in those models, p14 reverses the antimigratory effect of endocan. To conclude, our study supports the hypothesis of an antagonistic role of p14 vs. endocan in its effect on the LFA-1/ICAM-1-dependent human leukocyte recruitment.
In some applications, this compound(4897-25-0)COA of Formula: C4H4ClN3O2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts