Safety of P(t-Bu)3 Pd G3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: P(t-Bu)3 Pd G3, is researched, Molecular C25H40NO3PPdS, CAS is 1445086-17-8, about Palladium/Xu-Phos-catalyzed enantioselective cascade Heck/remote C(sp2) -H alkylation reaction. Author is Xu, Bing; Ji, Danting; Wu, Lizuo; Zhou, Lujia; Liu, Yu; Zhang, Zhan-Ming; Zhang, Junliang.
A robust Heck-type difunctionalization of a broad range of unactivated alkenes enabled by the first palladium/Xu-Phos-catalyzed tandem Heck/remote C-H bond alkylation was demonstrated. Moreover, both enantiomers of the product can be efficiently prepared using the same enantiomer of a chiral ligand via a position of the Ph ring-dependent enantiodivergent synthesis. The salient features of this methodol. include operational simplicity, high chemo- and enantio-selectivities and broad substrate scope. In addition, the C(sp2)-H activation, alkene insertion and C-I reductive elimination steps are reversible by experiments
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts