The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ) is researched.Recommanded Product: 2,4,5-Triphenylimidazole.Naidoo, Shivani; Jeena, Vineet published the article 《Molecular iodine/DMSO mediated oxidation of internal alkynes and primary alcohols using a one-pot, two step approach towards 2,4,5-trisubstituted imidazoles: Substrate scope and mechanistic studies》 about this compound( cas:484-47-9 ) in Tetrahedron. Keywords: imidazole preparation green chem; aryl alkyne primary alc tandem oxidation. Let’s learn more about this compound (cas:484-47-9).
An efficient, eco-friendly and practical oxidation of internal alkynes R1CCR2 (R1 = Ph, 4-bromophenyl; R2 = Ph, 4-bromophenyl, 4-chlorophenyl) and primary alcs. R3CH2OH (R3 = furan-2-yl, naphthalen-2-yl, cyclohexyl, etc.) as key steps towards the synthesis of 2,4,5-trisubstituted imidazoles I is reported. This green synthetic methodol. employed an acid and metal-free mol. iodine/DMSO system to afford a variety of substituted imidazoles I in moderate to good yields, with a range of functionalities tolerated. Mechanistic studies revealed two distinct oxidation pathways, which ultimately form the benzil and benzaldehyde that serve as key intermediates in the multicomponent domino synthesis.
In some applications, this compound(484-47-9)Recommanded Product: 2,4,5-Triphenylimidazole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts